Oximes have been studied for decades because of their significant roles as
acetylcholinesterase reactivators. Over the last twenty years, a large number of oximes have …

This review highlights the potential role of cyclooxygenase-2 enzyme (COX-2) in the
pathogenesis of Alzheimer's disease (AD) and the potential therapeutic use of non-steroidal …

To discover fungicides with novel targets, a series of N-acyl-1, 2, 3, 4-tetrahydroquinoline
(NATHQ) derivatives were designed and synthesized by linking the active substructure …

Knowledge of glycogen synthase kinase 3β (GSK3β) activity and the molecules identified
that regulate its function in infections caused by pathogenic microorganisms is crucial to …

Background Insufficient solubility and stability of bioactive small molecules as well as poor
biocompatibility may cause low bioavailability and are common obstacles in drug …

Ethnopharmacological relevance Asthma is a chronic airway inflammatory disease that can
lead to several complications caused by bacterial infections. However, recurrent attacks of …

Abstract Background Danggui Longhui is a traditional Chinese medicine made from the
dried root of Angelica sinensis. It is used in psychiatric patients in China to reduce …

Osteolytic bone destruction is found in approximately 60% of advanced breast cancer
patients. With the pathogenesis of bone metastasis being unclear, traditional antiresorptive …

The effective pharmacological treatment of inflamed wounds such as pyoderma
gangraenosum remains challenging, as the systemic application of suitable drugs such as …

Targeting protein kinases that regulate signalling pathways in inflammation is an effective
pharmacological approach to alleviate uncontrolled inflammatory diseases. In this context …