Minamata disease in Japan and the large-scale poisoning by methylmercury (MeHg) in Iraq
caused wide public concerns about the risk emanating from mercury for human health …

Adverse outcome pathways (AOPs) are a recent toxicological construct that connects, in a
formalized, transparent and quality-controlled way, mechanistic information to apical …

Multiple non-animal-based test methods have never been formally validated. In order to use
such new approach methods (NAMs) in a regulatory context, criteria to define their …

There is a paucity of information concerning the developmental neurotoxicity (DNT) hazard
posed by industrial and environmental chemicals. New testing approaches will most likely …

A major reason for the current reproducibility crisis in the life sciences is the poor
implementation of quality control measures and reporting standards. Improvement is …

The call for a paradigm change in toxicology from the United States National Research
Council in 2007 initiates awareness for the invention and use of human‐relevant alternative …

Neurotoxicity and developmental neurotoxicity are important issues of chemical hazard
assessment. Since the interpretation of animal data and their extrapolation to man is …

Read-across (RAx) translates available information from well-characterized chemicals to a
substance for which there is a toxicological data gap. The OECD is working on case studies …

The last talks, given by academic researchers, were geared to set the stage for breakout
group discussions. They reviewed the scientific principles of alternative DNT methods to test …

Despite a major role of experimental animals in development of biomedical research, there
has been historical controversy surrounding animal research. Along with a strategy of 3Rs …