Haematological (blood) cancers are the cancers of the blood and lymphoid forming tissues
which represents approximately 10% of all cancers. It has been reported that approximately …

Considering the potential of mucoadhesive properties of nanoparticles in oral delivery, this
work describes the preparation and characterization of fucoidan/chitosan nanoparticles …

Silencing of tumor suppressor genes by promoter hypermethylation is a key mechanism to
facilitate cancer progression in many malignancies. While promoter hypermethylation can …

Background In the present study, we investigated the molecular mechanisms underlying the
pro-apoptotic effects of quercetin (Qu) by evaluating the effect of Qu treatment on DNA …

Background Promoter methylation of O6-methylguanine-DNA methyltransferase (MGMT) is
an important predictive biomarker in glioblastoma. The T variant of the MGMT promoter …

Background The prognostic value of aberrant DNA methylation of cell-free circulating DNA
in plasma has not previously been evaluated in diffuse large B cell lymphoma (DLBCL). The …

Introduction It has been shown in some articles that genetic and epigenetic abnormalities
cannot only be found in tumor tissues but also in adjacent regions that appear histologically …

Pyrosequencing, a real-time sequencing technology, is considered a “gold standard” for
quantitative allele quantification at single base resolution. Quantitative bisulfite …

Background Resistance of the highly aggressive glioblastoma multiforme (GBM) to drug
therapy is a major clinical problem resulting in a poor patient's prognosis. Beside promoter …

Promoter methylation represents one of the major epigenetic mechanisms responsible for
the regulation of gene expression. Hypomethylating drugs are currently approved for the …