The article discusses the association of gene polymorphisms and periodontitis, and the
interaction of genes and the environment. It says that distribution of genetic polymorphisms …

Variants of the arachidonate 5-lipoxygenase-activating protein (ALOX5AP) gene have been
implicated as a risk factor for stroke. However, genetic association studies that have …

Abstract Associations between 5, 10-methylenetetrahydrofolate reductase (MTHFR) gene
C677T polymorphism and ischemic stroke have been reported (Ariyaratnam et al., 2007; …

Detection of interacting risk factors for complex traits is challenging. The choice of an
appropriate method, sample size, and allocation of cases and controls are serious concerns …

Background: Variants in the 5-lipoxygenase-activating protein (ALOX5AP) and
phosphodiesterase 4D (PDE4D) genes have first been associated with ischemic stroke (IS) …

Stroke is a multifactorial disease responsible for nearly 10% of deaths each year in
industrialized countries. While some monogenic forms of stroke have been described, the …

Objective: The 5-lipoxygenase catalyzed formation of leukotriene lipid mediators is a
mediator for inflammatory response in arteries. The present study investigated the …

Stroke is a common complex trait and does not follow Mendelian pattern of inheritance.
Gene–gene or gene–environment interactions may be responsible for the complex trait …

BACKGROUND: Previous studies concerning the association between
methylenetetrahydrofolate reductase (MTHFR) C677T polymorphism and risk of …

Abstract Background/Aims: To investigate the roles of the oxidative stress related-genes
ALOX5, ALOX5AP and MPO in ischemic stroke susceptibility in the Han Chinese population …