The yeast deletion collection: a decade of functional genomics
The yeast deletion collections comprise> 21,000 mutant strains that carry precise start-to-
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
stop deletions of∼ 6000 open reading frames. This collection includes heterozygous and …
[HTML][HTML] Thermotolerant fermenting yeasts for simultaneous saccharification fermentation of lignocellulosic biomass
Lignocellulosic biomass is the most abundant renewable source of energy that has been
widely explored as second-generation biofuel feedstock. Despite more than four decades of …
widely explored as second-generation biofuel feedstock. Despite more than four decades of …
A global genetic interaction network maps a wiring diagram of cellular function
INTRODUCTION Genetic interactions occur when mutations in two or more genes combine
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
to generate an unexpected phenotype. An extreme negative or synthetic lethal genetic …
Precise, automated control of conditions for high-throughput growth of yeast and bacteria with eVOLVER
BG Wong, CP Mancuso, S Kiriakov, CJ Bashor… - Nature …, 2018 - nature.com
Precise control over microbial cell growth conditions could enable detection of minute
phenotypic changes, which would improve our understanding of how genotypes are shaped …
phenotypic changes, which would improve our understanding of how genotypes are shaped …
[HTML][HTML] Cellular control of viscosity counters changes in temperature and energy availability
LB Persson, VS Ambati, O Brandman - Cell, 2020 - cell.com
Cellular functioning requires the orchestration of thousands of molecular interactions in time
and space. Yet most molecules in a cell move by diffusion, which is sensitive to external …
and space. Yet most molecules in a cell move by diffusion, which is sensitive to external …
Functional metabolomics describes the yeast biosynthetic regulome
Genome-metabolism interactions enable cell growth. To probe the extent of these
interactions and delineate their functional contributions, we quantified the Saccharomyces …
interactions and delineate their functional contributions, we quantified the Saccharomyces …
rDNA array length is a major determinant of replicative lifespan in budding yeast
The complex processes and interactions that regulate aging and determine lifespan are not
fully defined for any organism. Here, taking advantage of recent technological advances in …
fully defined for any organism. Here, taking advantage of recent technological advances in …
Genetic effects on molecular network states explain complex traits
M Weith, J Großbach, M Clement‐Ziza… - Molecular Systems …, 2023 - embopress.org
The complexity of many cellular and organismal traits results from the integration of genetic
and environmental factors via molecular networks. Network structure and effect propagation …
and environmental factors via molecular networks. Network structure and effect propagation …
Modifying yeast tolerance to inhibitory conditions of ethanol production processes
Saccharomyces cerevisiae strains having a broad range of substrate utilization, rapid
substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory …
substrate consumption, and conversion to ethanol, as well as good tolerance to inhibitory …
Considerations for the use of transcriptomics in identifying the 'genes that matter'for environmental adaptation
TG Evans - The Journal of experimental biology, 2015 - journals.biologists.com
Transcriptomics has emerged as a powerful approach for exploring physiological responses
to the environment. However, like any other experimental approach, transcriptomics has its …
to the environment. However, like any other experimental approach, transcriptomics has its …