EGFR signaling pathway as therapeutic target in human cancers

E Levantini, G Maroni, M Del Re, DG Tenen - Seminars in cancer biology, 2022 - Elsevier
Abstract Epidermal Growth Factor Receptor (EGFR) enacts major roles in the maintenance
of epithelial tissues. However, when EGFR signaling is altered, it becomes the grand …

Aptamer-based probes for cancer diagnostics and treatment

X Hu, D Zhang, Z Zeng, L Huang, X Lin, S Hong - Life, 2022 - mdpi.com
Aptamers are single-stranded DNA or RNA oligomers that have the ability to generate
unique and diverse tertiary structures that bind to cognate molecules with high specificity. In …

[HTML][HTML] Extracellular vesicles in anti-tumor immunity

E Vergani, E Daveri, V Vallacchi, L Bergamaschi… - Seminars in Cancer …, 2022 - Elsevier
To what extent extracellular vesicles (EVs) can impact anti-tumor immune responses has
only started to get unraveled. Their nanometer dimensions, their growing number of …

EFEMP2 upregulates PD-L1 expression via EGFR/ERK1/2/c-Jun signaling to promote the invasion of ovarian cancer cells

X Shen, X Jin, S Fang, J Chen - Cellular & Molecular Biology Letters, 2023 - Springer
Background Fibulin-like extracellular matrix protein 2 (EFEMP2) has been reported to be
related to the progression of various cancers. We have previously reported that EFEMP2 …

Nasopharyngeal carcinoma: The role of the EGFR in epstein–barr virus infection

X Peng, Y Zhou, Y Tao, S Liu - Pathogens, 2021 - mdpi.com
Epstein–Barr virus (EBV), a type 4 γ herpes virus, is recognized as a causative agent in
nasopharyngeal carcinoma (NPC). Incidence of EBV-positive NPC have grown in recent …

[HTML][HTML] Complex RNA world in small extracellular vesicles for liquid biopsy in cancer management

S Wang, Y Lin, Y Zhang, X Qiu, Y Pan, SCJ Yeung… - Extracellular …, 2022 - Elsevier
Liquid biopsy is a valuable tool in oncology with its advantages of non-invasiveness,
longitudinal sampling, and capturing the intra-and inter-tumor heterogeneity. Small …

Osteoclast-derived extracellular vesicles are implicated in sensory neurons sprouting through the activation of epidermal growth factor signaling

E Neto, L Leitão, JC Mateus, DM Sousa, CJ Alves… - Cell & bioscience, 2022 - Springer
Background Different pathologies, affecting the skeletal system, were reported to display
altered bone and/or cartilage innervation profiles leading to the deregulation of the tissue …

[HTML][HTML] Delineating the role of extracellular vesicles in cancer metastasis: A comprehensive review

M Majood, S Rawat, S Mohanty - Frontiers in Immunology, 2022 - frontiersin.org
Extracellular vesicles (EVs) are subcellular messengers that aid in the formation and spread
of cancer by enabling tumor-stroma communication. EVs develop from the very porous …

Extracellular vesicles: A novel tool facilitating personalized medicine and pharmacogenomics in oncology

K Goričar, V Dolžan, M Lenassi - Frontiers in pharmacology, 2021 - frontiersin.org
Biomarkers that can guide cancer therapy based on patients' individual cancer molecular
signature can enable a more effective treatment with fewer adverse events. Data on …

Epidermal growth factor signalling pathway in endochondral ossification: an evidence-based narrative review

L Mangiavini, GM Peretti, B Canciani… - Annals of Medicine, 2022 - Taylor & Francis
During endochondral bone development, a complex process that leads to the formation of
the majority of skeletal elements, mesenchymal cells condense, differentiating into …