Comparative structure and function analysis of the RIG-I-like receptors: RIG-I and MDA5
RIG-I (Retinoic acid-inducible gene I) and MDA5 (Melanoma Differentiation-Associated
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
protein 5), collectively known as the RIG-I-like receptors (RLRs), are key protein sensors of …
[HTML][HTML] The role of RNA interference (RNAi) in arbovirus-vector interactions
CD Blair, KE Olson - Viruses, 2015 - mdpi.com
RNA interference (RNAi) was shown over 18 years ago to be a mechanism by which
arbovirus replication and transmission could be controlled in arthropod vectors. During the …
arbovirus replication and transmission could be controlled in arthropod vectors. During the …
DENV inhibits type I IFN production in infected cells by cleaving human STING
Dengue virus (DENV) is a pathogen with a high impact on human health. It replicates in a
wide range of cells involved in the immune response. To efficiently infect humans, DENV …
wide range of cells involved in the immune response. To efficiently infect humans, DENV …
Incoming RNA virus nucleocapsids containing a 5′-triphosphorylated genome activate RIG-I and antiviral signaling
M Weber, A Gawanbacht, M Habjan, A Rang… - Cell host & …, 2013 - cell.com
Host defense to RNA viruses depends on rapid intracellular recognition of viral RNA by two
cytoplasmic RNA helicases: RIG-I and MDA5. RNA transfection experiments indicate that …
cytoplasmic RNA helicases: RIG-I and MDA5. RNA transfection experiments indicate that …
Sequence Analysis of In Vivo Defective Interfering-Like RNA of Influenza A H1N1 Pandemic Virus
K Saira, X Lin, JV DePasse, R Halpin… - Journal of …, 2013 - Am Soc Microbiol
Influenza virus defective interfering (DI) particles are naturally occurring noninfectious
virions typically generated during in vitro serial passages in cell culture of the virus at a high …
virions typically generated during in vitro serial passages in cell culture of the virus at a high …
Influenza A virus panhandle structure is directly involved in RIG-I activation and interferon induction
Retinoic acid-inducible gene I (RIG-I) is an important innate immune sensor that recognizes
viral RNA in the cytoplasm. Its nonself recognition largely depends on the unique RNA …
viral RNA in the cytoplasm. Its nonself recognition largely depends on the unique RNA …
ATPase‐driven oligomerization of RIG‐I on RNA allows optimal activation of type‐I interferon
The cytosolic pathogen sensor RIG‐I is activated by RNAs with exposed 5′‐triphosphate
(5′‐ppp) and terminal double‐stranded structures, such as those that are generated during …
(5′‐ppp) and terminal double‐stranded structures, such as those that are generated during …
A Sendai virus-derived RNA agonist of RIG-I as a virus vaccine adjuvant
The innate immune system is responsible for recognizing invading pathogens and initiating
a protective response. In particular, the retinoic acid-inducible gene 1 protein (RIG-I) …
a protective response. In particular, the retinoic acid-inducible gene 1 protein (RIG-I) …
Paramyxovirus V proteins interact with the RIG-I/TRIM25 regulatory complex and inhibit RIG-I signaling
MT Sanchez-Aparicio, LJ Feinman… - Journal of …, 2018 - Am Soc Microbiol
Paramyxovirus V proteins are known antagonists of the RIG-I-like receptor (RLR)-mediated
interferon induction pathway, interacting with and inhibiting the RLR MDA5. We report …
interferon induction pathway, interacting with and inhibiting the RLR MDA5. We report …
Nonsegmented Negative-Sense RNA Viruses Utilize N6-Methyladenosine (m6A) as a Common Strategy To Evade Host Innate Immunity
ABSTRACT N 6-Methyladenosine (m6A) is the most abundant internal RNA modification
catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many viruses …
catalyzed by host RNA methyltransferases. As obligate intracellular parasites, many viruses …