Introduction: Gene therapy mainly depends on the use of appropriate delivery vehicles with
no induction of immune responses and toxicity. The limitations of viral gene carriers such as …

Nowadays, small non-coding Ribo Nucleic Acids (sncRNAs) such as siRNA, miRNA and
shRNA are extremely serving to gene regulation. They are involved in many biological …

Poor solubility of crocetin has limited its use as a potential chemotherapeutic agent. In this
study, a crocetin nanocarrier was formulated based on poly (lactic-co-glycolic acid)(PLGA) …

Some microorganisms belonging to the Mycobacterium tuberculosis (Mtb) complex produce
an airborne infectious disease, called tuberculosis (TB). Robert Koch discovered this …

Gene therapy is extensively studied as a realistic and promising therapeutic approach for
treating inherited and acquired diseases by repairing defective genes through introducing …

In recent years, much effort has been focused on an appropriate combination of
chemotherapeutic drugs and nucleic acids to exploit additive or synergistic therapeutic …

Synthetic polymers, such as dendrimers, play a critical role in pharmaceutical discovery and
development. Advances in the application of nanotechnology in medicine have given rise to …

Abstract Poly-(amidoamine)(PAMAM) and poly-(propylenimine)(PPI) are the two most widely
investigated dendrimers for drug and gene delivery. In order to enhance DNA transfection …

Poor water solubility of hydrophobic drugs is one of the major problems in pharmaceutical
sciences. Herein, in order to address the poor solubility of crocetin, the 30% of primary …

Gene therapy, as a novel therapeutic strategy, is used to treat various diseases.
Nevertheless, gene carriers are necessary for gene therapy. Among them, polycationic gene …