Purpose Low back pain (LBP) is the most disabling condition worldwide. Although LBP
relates to different spinal pathologies, vertebral bone marrow lesions visualized as Modic …

Intervertebral disc degeneration (IDD) is the major cause of low back pain which incurs a
significant public‐health and economic burden. The aetiology of IDD is complex, with …

Abstract Background Context Modic changes (MC) are bone marrow lesions on magnetic
resonance imaging (MRI), suggestive of being associated with low back pain (LBP). Data on …

It is believed that disc degeneration (DD) is, in general, only mildly associated with low back
pain (LBP). MRI-identified Modic changes (MC), probably a late stage of DD, are relatively …

Study Design. Longitudinal cohort study of twins representative of the general population.
Objective. To assess the relationship between Modic change (MC) and severe, disabling …

Low back pain (LBP) is the world's most disabling condition. Modic changes (MC) are
vertebral bone marrow changes adjacent to the endplates as noted on magnetic resonance …

Body mass index (BMI)(calculated as weight (kg)/height (m) 2) and height are linked to the
pathogenesis of low back pain, but evidence-based confirmation is lacking. We examined …

Background Estimating the contribution of endplate oedema known as Modic changes to
lower back pain (LBP) has been the subject of multiple observational studies and reviews …

Background context Modic changes (MC) are associated with low back pain. They represent
vertebral endplate and adjacent vertebral marrow changes on magnetic resonance imaging …

Pinealectomy in vertebrates accelerated intervertebral disk degeneration (IDD). However,
the potential mechanisms, particularly melatonin's role, are still to be clarified. In this study …