Motor neurons (MNs) are neuronal cells located in the central nervous system (CNS)
controlling a variety of downstream targets. This function infers the existence of MN subtypes …

Gli zinc-finger proteins are transcription factors involved in the intracellular signal
transduction controlled by the Hedgehog family of secreted molecules. They are frequently …

Human brain organoids generated with current technologies recapitulate histological
features of the human brain, but they lack a reproducible topographic organization. During …

The exteroceptive somatosensory system is important for reflexive and adaptive behaviors
and for the dynamic control of movement in response to external stimuli. This review outlines …

Neuronal subtype specification in the vertebrate neural tube is one of the best-studied
examples of embryonic pattern formation. Distinct neuronal subtypes are generated in a …

The progressive loss of CNS myelin in patients with multiple sclerosis (MS) has been
proposed to result from the combined effects of damage to oligodendrocytes and failure of …

The Hedgehog (Hh) signaling pathway is of central importance during embryo development
in metazoans and governs a diverse array of processes including cell proliferation …

Morphogens act in developing tissues to control the spatial arrangement of cellular
differentiation,. The activity of a morphogen has generally been viewed as a concentration …

Homozygosity for the G allele of rs6983267 at 8q24 increases colorectal cancer (CRC)
risk∼ 1.5 fold. We report here that the risk allele G shows copy number increase during …

Recent studies have revealed unexpected connections between the mammalian Hedgehog
(Hh) signal transduction pathway and the primary cilium, a microtubule-based organelle that …