Biomarkers for parkinsonian disorders in CNS-originating EVs: promise and challenges

S Dutta, S Hornung, HB Taha, G Bitan - Acta neuropathologica, 2023 - Springer
Extracellular vesicles (EVs), including exosomes, microvesicles, and oncosomes, are nano-
sized particles enclosed by a lipid bilayer. EVs are released by virtually all eukaryotic cells …

Extracellular Vesicles for the Diagnosis of Parkinson's Disease: Systematic Review and Meta‐Analysis

M Xylaki, A Chopra, S Weber, M Bartl… - Movement …, 2023 - Wiley Online Library
Parkinson's disease (PD) biomarkers are needed by both clinicians and researchers (for
diagnosis, identifying study populations, and monitoring therapeutic response). Imaging …

Biomarker and therapeutic potential of peripheral extracellular vesicles in Alzheimer's disease

C Vandendriessche, D Kapogiannis… - Advanced drug delivery …, 2022 - Elsevier
Extracellular vesicles (EVs) are cell-derived nanoparticles with an important role in
intercellular communication, even across brain barriers. The bidirectional brain-barrier …

Extracellular vesicles as mediators of neuroinflammation in intercellular and inter-organ crosstalk

A Cabrera-Pastor - International Journal of Molecular Sciences, 2024 - mdpi.com
Neuroinflammation, crucial in neurological disorders like Alzheimer's disease, multiple
sclerosis, and hepatic encephalopathy, involves complex immune responses. Extracellular …

Engineering exosomes for therapeutic applications: decoding biogenesis, content modification, and cargo loading strategies

M Bahadorani, M Nasiri, K Dellinger… - International Journal …, 2024 - Taylor & Francis
Exosomes emerge from endosomal invagination and range in size from 30 to 200 nm.
Exosomes contain diverse proteins, lipids, and nucleic acids, which can indicate the state of …

Dual role of brain-derived extracellular vesicles in dementia-related neurodegenerative disorders: cargo of disease spreading signals and diagnostic-therapeutic …

F Natale, S Fusco, C Grassi - Translational Neurodegeneration, 2022 - Springer
Neurodegenerative disorders are one of the most common causes of disability and
represent 6.3% of the global burden of disease. Among them, Alzheimer's, Parkinson's, and …

Comparative assessment of Alzheimer's disease-related biomarkers in plasma and neuron-derived extracellular vesicles: a nested case-control study

A Manolopoulos, F Delgado-Peraza… - Frontiers in Molecular …, 2023 - frontiersin.org
Introduction: Alzheimer's disease (AD) is currently defined according to biomarkers reflecting
the core underlying neuropathological processes: Aβ deposition, Tau, and …

Challenges in anti‐aging medicine–trends in biomarker discovery and therapeutic interventions for a healthy lifespan

I Popescu, J Deelen, M Illario… - Journal of Cellular and …, 2023 - Wiley Online Library
We are facing a growing aging population, along with increasing pressure on health
systems, caused by the impact of chronic co‐morbidities (ie cancer, cardiovascular and …

Plasma versus serum for extracellular vesicle (EV) isolation: A duel for reproducibility and accuracy for CNS‐originating EVs biomarker analysis

HB Taha - Journal of Neuroscience Research, 2023 - Wiley Online Library
Blood‐derived extracellular vesicles (EVs) are a popular source of biomarkers for central
nervous system (CNS) diseases, but inconsistencies in isolation and analysis hinder their …

Evaluation of α‐synuclein in CNS‐originating extracellular vesicles for parkinsonian disorders: a systematic review and meta‐analysis

HB Taha, SS Ati - CNS Neuroscience & Therapeutics, 2023 - Wiley Online Library
Abstract Background & Aims Parkinsonian disorders, such as Parkinson's disease (PD),
multiple system atrophy (MSA), dementia with Lewy bodies (DLB), progressive supranuclear …