Shear rheology of fluid interfaces: Closing the gap between macro-and micro-rheology

E Guzmán, J Tajuelo, JM Pastor, MÁ Rubio… - Current opinion in …, 2018 - Elsevier
For many years the determination of the shear viscosity of interfacial layers has been source
of strong controversy. This is mainly because different techniques provided different values …

Physicochemical factors of bioprocessing impact the stability of therapeutic proteins

LM Pandey - Biotechnology Advances, 2022 - Elsevier
The aggregation of therapeutic proteins is potentially encountered during various steps such
as bioprocessing, formulation, storage, transportation and administration. The aggregation …

Shear-induced crystallization and rheological analysis of a therapeutic protein

J Ferreira, J Carneiro, JM de Campos - Crystal Growth & Design, 2022 - ACS Publications
Crystallization is an attractive alternative for protein-based therapeutic formulations since the
crystalline form offers improved stability, longer storage lifetime, and enables controlled …

Amyloidogenesis via interfacial shear in a containerless biochemical reactor aboard the International Space Station

P McMackin, J Adam, S Griffin, A Hirsa - npj Microgravity, 2022 - nature.com
Fluid interfaces significantly influence the dynamics of protein solutions, effects that can be
isolated by performing experiments in microgravity, greatly reducing the amount of solid …

Effects of shear rate and protein concentration on amyloidogenesis via interfacial shear

JA Adam, HR Middlestead, NE Debono… - The Journal of …, 2021 - ACS Publications
The influence of hydrodynamics on protein fibrillization kinetics is relevant to biophysics,
biochemical reactors, medicine, and disease. This investigation focused on the effects of …

Classical and Nonclassical Nucleation Mechanisms of Insulin Crystals

J Ferreira, V Domínguez-Arca, J Carneiro, G Prieto… - ACS …, 2024 - ACS Publications
Although the Classical Nucleation Theory (CNT) is the most consensual theory to explain
protein nucleation mechanisms, experimental observations during the shear-induced …

Insulin crystallization: The route from hanging-drop vapour diffusion to controlled crystallization in droplet microfluidics

J Ferreira, Z Sarkany, F Castro, F Rocha… - Journal of Crystal Growth, 2022 - Elsevier
Although half a century has passed since the mapping of the insulin structure, this globular
protein is still currently being investigated. Crystalline drug formulations might replace the …

The effect of surface viscosity on the translational speed of droplets

V Narsimhan - Physics of Fluids, 2018 - pubs.aip.org
This paper quantifies the effect of interfacial viscosity on the translational speed of a drop in
Stokes flow. In the limit of negligible droplet deformation and surface concentration …

Single-camera PTV within interfacially sheared drops in microgravity

PM McMackin, JA Adam, FP Riley, AH Hirsa - Experiments in Fluids, 2023 - Springer
Abstract Development of experimental methods for in situ particle tracking velocimetry (PTV)
is fundamental for allowing measurement of moving systems non-tailored for velocimetry …

Between no slip and free slip: a new boundary condition for the surface hydrodynamics of a molten metal

K Patouillet, L Davoust - Chemical Engineering Science, 2021 - Elsevier
As an attempt to take into account the mechanical role of oxide films at the liquid surface of
melted or liquid metal flows, a model is proposed based on a Boussinesq-Scriven law …