Intracellular pathogens have developed elaborate mechanisms to exploit the different
cellular systems of their unwilling hosts to facilitate their entry, replication, and survival. In …

Highlights•High entropy of intrinsically disordered regions (IDRs) forms the basis for
functional plasticity.•Inherent features of IDRs are optimised to overcome the entropic cost of …

Global health is threatened by emerging viral infections, which largely lack effective
vaccines or therapies. Targeting host pathways that are exploited by multiple viruses could …

The Arp2/3 complex consists of seven evolutionarily conserved subunits (Arp2, Arp3 and
ARPC1–5) and plays an essential role in generating branched actin filament networks …

Eukaryotic cells are densely packed with macromolecular complexes and intertwining
organelles, continually transported and reshaped. Intriguingly, organelles avoid clashing …

Cell migration is frequently accompanied by changes in cell morphology (morphodynamics)
on a range of spatial and temporal scales. Despite recent advances in imaging techniques …

A critical step in the life cycle of a virus is spread to a new target cell, which generally
involves the release of new viral particles from the infected cell which can then initiate …

Nck links phosphotyrosine-based signaling to Arp2/3-dependent actin polymerization during
many different cellular processes as well as actin-based motility of enteropathogenic …

Phosphotyrosine (pTyr) motifs in unstructured polypeptides orchestrate important cellular
processes by engaging SH2-containing adaptors to assemble complex signalling networks …

Invadopodia are actin‐rich membrane protrusions that digest the matrix barrier during
cancer metastasis. Since the discovery of invadopodia, they have been visualized as …