Protein handling, modification and folding in the endoplasmic reticulum (ER) are tightly
regulated processes that determine cell function, fate and survival. In several tumour types …

The high metabolic demand of cancer cells leads to an accumulation of H+ ions in the
tumour microenvironment. The disorganized tumour vasculature prevents an efficient wash …

Aberrant cell signaling can cause cancer and other diseases and is a focal point of drug
research. A common approach is to infer signaling activity of pathways from gene …

Acidosis, a common characteristic of the tumor microenvironment, is associated with
alterations in metabolic preferences of cancer cells and progression of the disease. Here we …

Tumors often show, compared to normal tissues, a markedly decreased extracellular pH
resulting from anaerobic or aerobic glycolysis in combination with a reduced removal of …

Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses
and characterized by extensive lipid peroxidation and membrane damages. The name of …

Packaging clinically relevant hydrophobic drugs into a self-assembled nanoparticle can
improve their aqueous solubility, plasma half-life, tumour-specific uptake and therapeutic …

Under hypoxic conditions, tumor cells undergo a series of adaptations that promote
evolution of a more aggressive tumor phenotype including the activation of DNA damage …

Mitochondrial phosphoenolpyruvate carboxykinase (PEPCK-M), encoded by the nuclear
PCK2 gene, links TCA cycle intermediates and glycolytic pools through the conversion of …

Background A variety of oncogenic and environmental factors alter tumor metabolism to
serve the distinct cellular biosynthetic and bioenergetic needs present during oncogenesis …