The function of neuronal circuits relies on the properties of individual neuronal cells and
their synapses. We propose that a substantial degree of synapse formation and function is …

Brain development relies on dynamic morphogenesis and interactions of neurons. Filopodia
are thin and highly dynamic membrane protrusions that are critically required for neuronal …

The evolutionary transition from diffusion-mediated cell-cell communication to faster,
targeted synaptic signaling in animal nervous systems is still unclear. Genome sequencing …

Stereotyped synaptic connections define the neural circuits of the brain. In vertebrates,
stimulus-independent activity contributes to neural circuit formation. It is unknown whether …

The mechanisms by which synaptic partners recognize each other and establish appropriate
numbers of connections during embryonic development to form functional neural circuits are …

For animals to perform coordinated movements requires the precise organization of neural
circuits controlling motor function. Motor neurons (MNs), key components of these circuits …

Following axon pathfinding, growth cones transition from stochastic filopodial exploration to
the formation of a limited number of synapses. How the interplay of filopodia and synapse …

INTRODUCTION Axons grow collateral branches to project to distinct target areas in the
central nervous system (CNS) and to form synapses with various postsynaptic partner cells …

Subarachnoid hemorrhage (SAH) is a devastating form of stroke that leads to incurable
outcomes. Increasing evidence has proved that early brain injury (EBI) contributes mostly to …

Developmental neuronal remodeling is crucial for proper wiring of the adult nervous system.
While remodeling of individual neuronal populations has been studied, how neuronal …