Gastrointestinal (GI) smooth muscle cell activity is controlled by contractile cholinergic
neurons and relaxant non-adrenergic non-cholinergic (NANC) neurons in the myenteric …

Gastrointestinal dysfunction is common in diabetic patients. In genetic (nonobese diabetic)
and toxin-elicited (streptozotocin) models of diabetes in mice, we demonstrate defects in …

Rationale: Sympathetic stimulation of the heart increases the force of contraction and rate of
ventricular relaxation by triggering protein kinase (PK) A-dependent phosphorylation of …

The first comprehensive single-source reference on the minipig, this accessible manual
provides a resource for research scientists on the potential and use of the minipig as a …

Nitric oxide (NO) is an important inhibitoryneurotransmitter in the gut. Alterations in NO
mediatedresponses have been described in diabetic animals. Thepresence of nitric oxide …

Phosphodiesterase 5 terminates the cellular actions of the second messenger molecule
cyclic GMP; inhibitors of phosphodiesterase 5 will therefore increase and prolong the …

Nitric oxide (NO) is a major inhibitory neurotransmitter that mediates nonadrenergic
noncholinergic (NANC) signaling. Neuronal NO synthase (nNOS) is activated by …

The morphological pattern and motor correlates of nitric oxide (NO) and vasoactive intestinal
polypeptide (VIP) innervation in the human isolated gastric fundus was explored. By using …

Post‐operative ileus (POI) is a serious condition which any horse undergoing abdominal
surgery is at risk of developing, leading to increased hospitalisation time and resulting costs …

Postoperative ileus (POI), a decrease in gastrointestinal motility after surgery, is an important
problem facing human and veterinary patients. 37.5% of horses that develop POI following …