Glutaminyl cyclase (QC) activity has been identified as a key effector in distinct biological
processes. Human glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-peptide …

Benzimidazole and benzoxazole derivatives are included in the category of medical drugs in
a wide range of areas such as anticancer, anticoagulant, antihypertensive, anti …

The objective of this work is to explore the effect and potential mechanism of Punicalagin
(Pun) in managing Alzheimer's disease (AD) based on computer-aided drug technology …

The toxic pyroglutamate form of amyloid-β (pE-Aβ) is important for the pathogenesis of early
Alzheimer's disease (AD); therefore, reducing pE-Aβ by inhibiting glutaminyl cyclase (QC) …

Human glutaminyl cyclase (hQC) is drawing considerable attention and emerging as a
potential druggable target for Alzheimer's disease (AD) due to its close involvement in the …

Glutaminyl cyclases, including glutaminyl-peptide cyclotransferase (QPCT) and glutaminyl-
peptide cyclotransferase-like protein (QPCTL), primarily catalyze the cyclization of N …

Glutaminyl cyclase (QC; isoform: isoQC) is a zinc-dependent enzyme that catalyzes the
intramolecular cyclization of N-terminal glutamine and glutamic acid residues into a …

Several new lines of research have demonstrated that a significant number of amyloid-β
peptides found in Alzheimer's disease (AD) are truncated and undergo post-translational …

Comprehensive Summary The cholinesterases are essential targets implicated in the
pathogenesis of Alzheimer's disease (AD). We have identified tryptophan …

Alzheimer's disease, the most common form of dementia, is characterized by the deposition
of amyloid plaques and neurofibrillary tangles in the brain, leading to the loss of neurons …