Adolescence is an evolutionarily conserved developmental phase characterized by
hormonal, physiological, neural and behavioral alterations evident widely across …

The adolescent transition is associated with increases in reward-and sensation-seeking,
peer-directed social interactions, and risk-taking, with exploratory use of alcohol and other …

Although women appear to be more vulnerable to alcohol-induced pathophysiology than
men, the neurobiological basis for sex differences is largely unknown, partially because …

Substance use and abuse begin during adolescence. Male and female adolescent humans
initiate use at comparable rates, but males increase use faster. In adulthood, more men than …

Background Alcohol use disorder is characterized by compulsive alcohol intake, or drinking
despite negative consequences. Previous studies have shown that female rodents have a …

Alcohol use, particularly binge drinking (BD), is a major public health concern among
adolescents. Recent national data show that the gender gap in alcohol use is lessening, and …

Background More women are being diagnosed with alcohol use disorder (AUD), are
increasing the amount of alcohol they are drinking, and are partaking in risky drinking …

One of the major functions of the orbitofrontal cortex (OFC) is to promote flexible motivated
behavior. It is no surprise, therefore, that recent work has demonstrated a prominent impact …

Adolescence is an evolutionarily conserved developmental period, with neural circuits and
behaviors contributing to the detection, procurement, and receipt of rewards bearing …

Adolescence is an evolutionarily conserved developmental period characterized by notable
maturational changes in the brain along with various age-related behavioral characteristics …