Systemic complications of acromegaly and the impact of the current treatment landscape: an update

MR Gadelha, L Kasuki, DST Lim… - Endocrine reviews, 2019 - academic.oup.com
Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Systemic complications of acromegaly: epidemiology, pathogenesis, and management

A Colao, D Ferone, P Marzullo, G Lombardi - Endocrine reviews, 2004 - academic.oup.com
This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Complications of acromegaly: cardiovascular, respiratory and metabolic comorbidities

R Pivonello, RS Auriemma, LFS Grasso, C Pivonello… - Pituitary, 2017 - Springer
Acromegaly is associated with an enhanced mortality, with cardiovascular and respiratory
complications representing not only the most frequent comorbidities but also two of the main …

A consensus on the diagnosis and treatment of acromegaly complications

S Melmed, FF Casanueva, A Klibanski, MD Bronstein… - Pituitary, 2013 - Springer
Abstract In March 2011, the Acromegaly Consensus Group met to revise and update the
guidelines on the diagnosis and treatment of acromegaly complications. The meeting was …

American Association of Clinical Endocrinologists medical guidelines for clinical practice for the diagnosis and treatment of acromegaly-2011 update

L Katznelson, JLD Atkinson, DM Cook… - Endocrine …, 2011 - endocrinepractice.org
AACE= American Association of Clinical Endocrinologists; BEL=“best evidence” level;
BMD= bone mineral density; CPAP= continuous positive airway pressure; CPG= clinical …

Place of cabergoline in acromegaly: a meta-analysis

L Sandret, P Maison, P Chanson - The Journal of Clinical …, 2011 - academic.oup.com
Context: Cabergoline is widely considered to be poorly effective in acromegaly. Objective:
The aim of this study was to obtain a more accurate picture of the efficacy of cabergoline in …

Acromegaly

P Chanson, S Salenave - Orphanet journal of rare diseases, 2008 - Springer
Acromegaly is an acquired disorder related to excessive production of growth hormone (GH)
and characterized by progressive somatic disfigurement (mainly involving the face and …

Growth hormone and pituitary radiotherapy, but not serum insulin-like growth factor-I concentrations, predict excess mortality in patients with acromegaly

J Ayuk, RN Clayton, G Holder… - The Journal of …, 2004 - academic.oup.com
Increased mortality in patients with acromegaly has been confirmed in a number of
retrospective studies, but causative factors and relationship to serum IGF-I remain uncertain …

The GH–IGF‐I axis and the cardiovascular system: clinical implications

A Colao - Clinical endocrinology, 2008 - Wiley Online Library
Summary Background GH and IGF‐I affect cardiac structure and performance. In the general
population, low IGF‐I has been associated with higher prevalence of ischaemic heart …

Clinical manifestations and diagnosis of acromegaly

G Lugo, L Pena, F Cordido - International journal of …, 2012 - Wiley Online Library
Acromegaly and gigantism are due to excess GH production, usually as a result of a pituitary
adenoma. The incidence of acromegaly is 5 cases per million per year and the prevalence is …