Inositol pyrophosphates (IPPs) are present in organisms ranging from plants, slime moulds
and fungi to mammals. Distinct classes of kinases generate different forms of energetic …

Cryptococcus neoformans is a common environmental saprophyte and human fungal
pathogen that primarily causes disease in immunocompromised individuals. Similar to many …

Cryptococcus neoformans is the leading cause of death by fungal meningoencephalitis;
however, treatment options remain limited. Here we report the construction of 264 signature …

Phosphatases, together with kinases and transcription factors, are key components in
cellular signalling networks. Here, we present a systematic functional analysis of the …

The ability of pathogenic fungi to acquire essential macro and micronutrients during infection
is a well-established virulence trait. Recent studies in the major human fungal pathogens …

In the human-pathogenic fungus Cryptococcus neoformans, the inositol polyphosphate
signaling pathway is critical for virulence. We recently demonstrated the key role of the …

The potential benefits of early patient access to new medicines in areas of high unmet
medical need are recognised, but uncertainties concerning effectiveness, safety and added …

Golgi reassembly and stacking protein (GRASP) is required for polysaccharide secretion
and virulence in Cryptococcus neoformans. In fungal species, extracellular vesicles (EVs) …

Inositol pyrophosphates are novel signaling molecules possessing high‐energy
pyrophosphate bonds and involved in a number of biological functions. Here, we report the …

Inorganic polyphosphate (polyP) which is ubiquitously present in both prokaryotic and
eukaryotic cells, consists of up to hundreds of orthophosphate residues linked by …