Dendrimer–and polymeric nanoparticle–aptamer bioconjugates as nonviral delivery systems: A new approach in medicine
S Mignani, X Shi, V Ceña, JP Majoral - Drug Discovery Today, 2020 - Elsevier
Highlights•Dendrimer-aptamer conjugates.•Polymer-aptamer conjugates.•Delivery
aptamers.•Cancer.Aptamers are RNA or DNA oligonucleotides interacting to form unique 3D …
aptamers.•Cancer.Aptamers are RNA or DNA oligonucleotides interacting to form unique 3D …
Improving breast cancer treatment specificity using aptamers obtained by 3D cell-SELEX
FHT Nelissen, WJM Peeters, TP Roelofs… - Pharmaceuticals, 2021 - mdpi.com
Three-dimensional spheroids of non-malignant MCF10A and malignant SKBR3 breast cells
were used for subsequent 3D Cell-SELEX to generate aptamers for specific binding and …
were used for subsequent 3D Cell-SELEX to generate aptamers for specific binding and …
Recombinant protein micelles to block transduction by SARS-CoV-2 pseudovirus
The continuing emergence of variants of the SARS-CoV-2 virus requires the development of
modular molecular therapies. Here, we engineered a recombinant amphiphilic protein …
modular molecular therapies. Here, we engineered a recombinant amphiphilic protein …
Macromolecular Effects in Medicinal Chemistry※
Drugs can be roughly divided into small molecule drugs (naturally extracted or chemically
synthesized) and macromolecular drugs (biologics) according to molecular weight. Although …
synthesized) and macromolecular drugs (biologics) according to molecular weight. Although …
药物化学中的大分子效应※
赵佳雨， 宋万通， 汤朝晖， 陈学思 - 化学学报, 2022 - sioc-journal.cn
摘要药物种类按照分子量来划分可以分为小分子药物(自然提取或化学合成的)
和大分子药物(生物制剂). 尽管目前小分子药物仍然是市场的主流, 但其研发增速趋缓 …
和大分子药物(生物制剂). 尽管目前小分子药物仍然是市场的主流, 但其研发增速趋缓 …
Conjugation of biphenyl groups with poly (ethylene glycol) to enhance inhibitory effects on the PD-1/PD-L1 immune checkpoint interaction
EH Kim, B Ning, M Kawamoto, H Miyatake… - Journal of Materials …, 2020 - pubs.rsc.org
Monoclonal antibodies have been developed as anticancer agents to block immune
checkpoint pathways associated with programmed cell death 1 (PD-1) and its ligand PD-L1 …
checkpoint pathways associated with programmed cell death 1 (PD-1) and its ligand PD-L1 …