Aldo–keto reductases comprise of AKR1C1–AKR1C4, four enzymes that catalyze NADPH
dependent reductions and have been implicated in biosynthesis, intermediary metabolism …

The xenobiotic metabolism in the lung, an organ of first entry of xenobiotics into the
organism, is crucial for inhaled compounds entering this organ intentionally (eg drugs) and …

Background Human cancer cell lines are used in research to study the biology of cancer and
to test cancer treatments. Recently there are already some large panels of several hundred …

Our understanding of the intracrine (or local) regulation of estrogen and other steroid
synthesis and degradation expanded in the last decades, also thanks to recent …

Abstract Aldo-keto reductase 1C3 (AKR1C3), one member of the aldo-keto reductase
superfamily, is involved in a variety of cancers. Recently, AKR1C3 has been demonstrated …

Pharmacokinetic drug resistance is a serious obstacle that emerges during cancer
chemotherapy. In this study, we investigated the possible role of aldo-keto reductase 1C3 …

The aim of the study was to identify a set of discriminating genes that could be used for the
prediction of Lymph node (LN) metastasis in human colorectal cancer (CRC), and for this …

Resistance to anticancer medications often leads to poor outcomes. The present study
explored an effective approach for enhancing chemotherapy targeted against human cancer …

Background Despite chemotherapy intensification, a subgroup of high-risk paediatric T-cell
acute lymphoblastic leukemia (T-ALL) patients still experience treatment failure. In this …

Purpose: OBI-3424 is a highly selective prodrug that is converted by aldo-keto reductase
family 1 member C3 (AKR1C3) to a potent DNA-alkylating agent. OBI-3424 has entered …