Experimental work during the past 15 years has demonstrated that endothelial cells in the
heart play an obligatory role in regulating and maintaining cardiac function, in particular, at …

Abstract Angiopoietins (ANG-1 and ANG-2) and their TIE-2 receptor tyrosine kinase have
wide-ranging effects on tumor malignancy that includes angiogenesis, inflammation, and …

Recent evidence shows the involvement of reactive oxygen species (ROS) in the mitogenic
cascade initiated by the tyrosine kinase receptors of several growth factor peptides. We have …

BACKGROUND/AIMS: Hepatocellular carcinoma (HCC) is a highly vascular tumor.
Angiopoietin-1 and Angiopoietin-2 have been shown to be involved in tumor angiogenesis …

Objective—Microvascular insufficiency represents a major cause of end-organ failure
among diabetics. The current studies were undertaken to determine whether dysregulation …

Recent studies have demonstrated that reactive oxygen species (ROS) mediate myocardial
ischemia-reperfusion (I/R) and angiogenesis via the mitogen-activated protein kinases and …

The angiopoietins/Tie-2 system is essential for the maintenance of vascular integrity and
angiogenesis. The functional role of angiopoietin-2 (Ang-2) in the regulation of …

Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are the two ligands of the Tie-2 receptor,
a receptor tyrosine kinase that is expressed on the endothelium. A balanced …

We hypothesised that angiopoietin-1 (Ang-1), in conjunction with vascular endothelial
growth factor (VEGF) gene therapy, can enhance arteriogenesis and angiogenesis during …

Angiogenic growth factors, vascular endothelial growth factor (VEGF) and angiopoietin-1
(Ang1) could decrease myocardial infarct size, which was assumed to be related with newly …