Global Cancer Statistics 2022: the trends projection analysis

BS Chhikara, K Parang - Chemical Biology Letters, 2023 - pubs.thesciencein.org
Cancer is one of the most fatal diseases of recent times that causes several deaths every
year. The disease variations in different parts of the world, the impact of available medical …

Indoles in multicomponent processes (MCPs)

M Shiri - Chemical reviews, 2012 - ACS Publications
In the last two or three decades the emphasis on and applications of green chemical
principles, introduced some significant advances in organic synthesis, such as combinatorial …

[图书][B] Indole ring synthesis: From natural products to drug discovery

GW Gribble - 2016 - books.google.com
Of the myriad of heterocycles known to man, the indole ring stands foremost for its
remarkably versatile chemistry, its enormous range of biological activities, and its ubiquity in …

Recent development in indole derivatives as anticancer agent: A mechanistic approach

N Devi, K Kaur, A Biharee… - Anti-Cancer Agents in …, 2021 - ingentaconnect.com
Background: Cancer accounts for several deaths each year. There are multiple FDA
approved drugs for cancer treatments. Due to the severe side effects and multiple drug …

[HTML][HTML] Indole derivatives as potential anticancer agents: A review

H Sachdeva, J Mathur, A Guleria - Journal of the Chilean Chemical …, 2020 - SciELO Chile
Heterocyclic moiety serve as perfect framework on which pharmacophores can be effectively
attached to produce novel drugs. Among various heterocyclic compounds, nitrogen-based …

Nitrogen-fused heterocycles: Empowering anticancer drug discovery

T Biswas, RK Mittal, V Sharma, Kanupriya… - Medicinal …, 2024 - benthamdirect.com
The worldwide impact of cancer is further compounded by the constraints of current
anticancer medications, which frequently exhibit a lack of selectivity, raise safety …

Synthesis, antiviral activity, and induction of plant resistance of indole analogues bearing dithioacetal moiety

C Wei, J Zhang, J Shi, X Gan, D Hu… - Journal of agricultural …, 2019 - ACS Publications
A series of compounds with potential activity to induce plant resistance was synthesized
from indole and thiol compounds and methodically evaluated for antiviral activity. The results …

pdCSM-cancer: using graph-based signatures to identify small molecules with anticancer properties

R Al-Jarf, AGC de Sá, DEV Pires… - Journal of Chemical …, 2021 - ACS Publications
The development of new, effective, and safe drugs to treat cancer remains a challenging and
time-consuming task due to limited hit rates, restraining subsequent development efforts …

Natural products for drug discovery: discovery of gramines as novel agents against a plant virus

A Lu, T Wang, H Hui, X Wei, W Cui… - Journal of agricultural …, 2019 - ACS Publications
Plant viral diseases seriously affect crop yield and quality. The natural product gramine (1)
and its simple structural analogues 2–35 were synthesized from indoles, amines, and …

Spectroscopic, quantum chemical, molecular docking and in vitro anticancer activity studies on 5-Methoxyindole-3-carboxaldehyde

SC Jeyaseelan, R Premkumar, K Kaviyarasu… - Journal of Molecular …, 2019 - Elsevier
Abstract The FT-IR and FT-Raman spectra of 5-Methoxyindole-3-carboxaldehyde (MICA)
molecule were recorded. The experimental and theoretical vibrational wavenumbers were …