Transposable elements and human diseases: mechanisms and implication in the response to environmental pollutants

B Chénais - International journal of molecular sciences, 2022 - mdpi.com
Transposable elements (TEs) are recognized as major players in genome plasticity and
evolution. The high abundance of TEs in the human genome, especially the Alu and Long …

Transposable elements co-option in genome evolution and gene regulation

E Gasparotto, FV Burattin, V Di Gioia… - International Journal of …, 2023 - mdpi.com
The genome is no longer deemed as a fixed and inert item but rather as a moldable matter
that is continuously evolving and adapting. Within this frame, Transposable Elements (TEs) …

LINE1 are spliced in non-canonical transcript variants to regulate T cell quiescence and exhaustion

F Marasca, S Sinha, R Vadalà, B Polimeni, V Ranzani… - Nature …, 2022 - nature.com
How gene expression is controlled to preserve human T cell quiescence is poorly
understood. Here we show that non-canonical splicing variants containing long interspersed …

Transposons contribute to the functional diversification of the head, gut, and ovary transcriptomes across Drosophila natural strains

M Coronado-Zamora, J González - Genome research, 2023 - genome.cshlp.org
Transcriptomes are dynamic, with cells, tissues, and body parts expressing particular sets of
transcripts. Transposable elements (TEs) are a known source of transcriptome diversity; …

IRescue: uncertainty-aware quantification of transposable elements expression at single cell level

B Polimeni, F Marasca, V Ranzani… - Nucleic Acids …, 2024 - academic.oup.com
Transposable elements (TEs) are mobile DNA repeats known to shape the evolution of
eukaryotic genomes. In complex organisms, they exhibit tissue-specific transcription …

LINE1 modulate human T cell function by regulating protein synthesis during the life span

FV Burattin, R Vadalà, M Panepuccia, V Ranzani… - Science …, 2024 - science.org
The molecular mechanisms responsible for the heightened reactivity of quiescent T cells in
human early life remain largely elusive. Our previous research identified that quiescent adult …

Comprehensive In Silico Analysis of Retrotransposon Insertions within the Survival Motor Neuron Genes Involved in Spinal Muscular Atrophy

A Pinto, C Cunha, R Chaves, MER Butchbach, F Adega - Biology, 2022 - mdpi.com
Simple Summary Transposable elements are DNA sequences that can move throughout the
genome. They play essential roles in gene regulation and function. Spinal muscular atrophy …

[图书][B] Evolution and Eschatology: Genetic Science and the Goodness of God

G Finlay - 2021 - books.google.com
The genome revolution of the last twenty years has changed biology forever. It has provided
stunning insights into the evolution of species (such as ours) and the development of new …

RNA Regulatory Networks 2.0

FJ Enguita, AL Leitão, JS Mattick - International Journal of Molecular …, 2023 - mdpi.com
The central role of RNA molecules in cell biology has been an expanding subject of study
since the proposal of the “RNA world” hypothesis 60 years ago [1, 2]. The intrinsic functional …

Role of Transposable Elements in the Evolution of the Triticeae Genome

J Li, R Cai - Triticeae Genomics and Genetics, 2024 - cropscipublisher.com
Transposable elements (TEs) are ubiquitous components of genomes and play a significant
role in the evolution and diversification of the Triticeae tribe, which includes important cereal …