This narrative review highlights current evidence linking greater body fatness to risk of
various cancers, with focus on evidence from recent large cohort studies and pooled …

Background Evidence from observational studies and clinical trials suggests that the gut
microbiota is associated with cancer. However, the causal association between gut …

HPV-positive and HPV-negative head and neck squamous cell carcinoma (HNSCC) are
recognized as distinct entities. There remains uncertainty surrounding the causal effects of …

As the rates of obesity continue to rise across the world, there has been an increasing resort
to bariatric surgery amongst the options for treatment. Through the reproductive lifespan …

Background Observational studies have linked childhood obesity with elevated risk of
colorectal cancer; however, it is unclear if this association is causal or independent from the …

Mounting evidence suggests that body mass index (BMI) is inversely associated with the risk
of lung cancer. However, relatively few studies have explored this association in Asian …

Genome-wide association studies (GWAS) have accelerated the exploration of genotype–
phenotype associations, facilitating the discovery of replicable genetic markers associated …

Purpose Abdominal hernia (AH) is one of the most common clinical diseases. A large
number of observational studies have found that obesity is an important risk factor for AH …

Background: Findings from Mendelian randomization (MR) studies are conventionally
interpreted as lifelong effects, which typically do not provide insight into the molecular …

Genomic studies of inherited and acquired variation are changing the landscape of our
understanding of the causes of urologic cancers and providing important translational …