▪ Abstract Phenotypic variation for quantitative traits results from the segregation of alleles at
multiple quantitative trait loci (QTL) with effects that are sensitive to the genetic, sexual, and …

A central challenge in evolutionary biology is to identify genes underlying ecologically
important traits and describe the fitness consequences of naturally occurring variation at …

Association studies based on linkage disequilibrium (LD) can provide high resolution for
identifying genes that may contribute to phenotypic variation. We report patterns of local and …

Elucidating the genetic basis of adaptive population divergence is a goal of central
importance in evolutionary biology. In principle, it should be possible to identify …

We compare and contrast the genetic architecture of quantitative phenotypes in two
genetically well-characterized model organisms, the laboratory mouse, Mus musculus, and …

One of the oldest problems in evolutionary biology remains largely unsolved. Which
mutations generate evolutionarily relevant phenotypic variation? What kinds of molecular …

Publisher Summary On a worldwide basis, plant breeding has been one of the most
successful technologies developed in modern agriculture: its methods are opportunistic and …

Phenotypic variation for quantitative traits results from the simultaneous segregation of
alleles at multiple quantitative trait loci. Understanding the genetic architecture of …

Understanding the genetic basis of the physical and behavioural traits that distinguish
humans from other primates presents one of the great new challenges in biology. Of the …

The statistical power of five association study test statistics (two haplotype-based tests, two
marker-based tests, and the Transmission Disequilibrium Test–Q5) to detect single …