Analytical methods for determination of glutathione and glutathione disulfide in pharmaceuticals and biological fluids

A Hamad, M Elshahawy, A Negm… - Reviews in Analytical …, 2019 - degruyter.com
Glutathione is a natural tripeptide that plays a major role in different physiological processes
in the human body. Determination of glutathione in different body fluids and tissues is …

Glycerol as a new mobile phase modifier for green liquid chromatographic determination of ascorbic acid and glutathione in pharmaceutical tablets

A Habib, MM Mabrouk, M Fekry, FR Mansour - Journal of Pharmaceutical …, 2022 - Elsevier
Fixed dose combinations of glutathione and ascorbic acid are marketed due to the
synergetic effect of glutathione, which regenerates ascorbic acid, potentiates its action and …

[HTML][HTML] Molecular design, synthesis and anticancer activity of new thiopyrano [2, 3-d] thiazoles based on 5-hydroxy-1, 4-naphthoquinone (juglone)

I Ivasechko, A Lozynskyi, J Senkiv… - European journal of …, 2023 - Elsevier
Abstract A series of 11-substituted 9-hydroxy-3, 5, 10, 11-tetrahydro-2H-benzo [6, 7]
thiochromeno [2, 3-d][1, 3] thiazole-2, 5, 10-triones 3.1–3.13 were synthesized via hetero …

Recent Advances in Separation Methods for Characterization of Glutathione Metabolism and Dietary Supplementation

M Kubát, E Roušarová, T Roušar, P Česla - TrAC Trends in Analytical …, 2024 - Elsevier
Glutathione (GSH) is the most important low-molecular intracellular antioxidant. In addition
to its antioxidant properties, it ensures many other biological functions, including the …

Neuroprotective effect of morin hydrate against attention-deficit/hyperactivity disorder (ADHD) induced by MSG and/or protein malnutrition in rat pups: Effect on …

HA Salem, N Elsherbiny, S Alzahrani, HM Alshareef… - Pharmaceuticals, 2022 - mdpi.com
Monosodium glutamate (MSG) is one of the most widely used food additives. However, it
has been linked to protein malnutrition (PM) and various forms of toxicities such as …

Intranasal cerium oxide nanoparticles ameliorate cognitive function in rats with Alzheimer's via anti-oxidative pathway

SM Danish, A Gupta, UA Khan, N Hasan, FJ Ahmad… - Pharmaceutics, 2022 - mdpi.com
Cerium oxide nanoparticles (CNPs), owing to their antioxidant property, have recently
emerged as therapeutic candidate for Alzheimer's disease (AD). However, intravenous …

Modulation of PI3K/Akt/GSK3β signaling cascade through G protein-coupled receptor 55 (GPR55) activation: prenatal lysophosphatidylinositol attenuates valproic …

S Ahmed, AH Abir, O Sharmin, N Khurshid, A Akter… - Life Sciences, 2023 - Elsevier
Abstract Aims Dysregulation of PI3K/Akt/GSK3β signaling has been implicated in various
neurological disorders, including autism spectrum disorder (ASD). G protein-coupled …

Dimethyl itaconate reprograms neurotoxic to neuroprotective primary astrocytes through the regulation of NLRP3 inflammasome and NRF2/HO-1 pathways

MD Khadem, MR Tabandeh, A Haschemi… - Molecular and Cellular …, 2022 - Elsevier
The activation of neurotoxic reactive astrocytes contributes to the pathogenesis of many
neurodegenerative diseases. Itaconate, a product of cellular metabolism, is released from …

The Developmental Hepatotoxicity of Titanium Dioxide Nanoparticles in NMRI Mouse Neonates

F Faisal, AH AbdulHussein, OH Salah… - Journal of …, 2023 - jns.kashanu.ac.ir
This study aimed to investigate the potential hepatotoxic effects of titanium dioxide
nanoparticles (TiO2 NPs) on neonatal NMRI mice through maternal milk exposure. A total of …

Analysis of copper-induced protein precipitation across the E. coli proteome

ATR Robison, GR Sturrock, JM Zaengle-Barone… - Metallomics, 2023 - academic.oup.com
Metal cations have been exploited for their precipitation properties in a wide variety of
studies, ranging from differentiating proteins from serum and blood to identifying the protein …