Metamizole (dipyrone) is a popular analgetic, non-opioid drug, commonly used in human
and veterinary medicine. In some cases, this agent is still incorrectly classified as a non …

Metamizole, also known as dipyrone, was introduced to the market nearly a century ago.
Due to its excellent analgesic, antipyretic, and spasmolytic properties combined with its …

The combination of non-steroidal anti-inflammatory drugs (NSAIDs) with non-opioid
analgesics is common in clinical practice for the treatment of acute painful conditions like …

Pain represents a complex experience which can be approached by various medicines. Non-
opioid and opioid analgesics are the most common drugs used to manage different types of …

Background: Dipyrone (metamizole) is one of the most widely used non-opioid analgesics
for the treatment of cancer pain. Aim: Because evidence-based recommendations are not …

Nitroso-3-trifluoromethyl-5-alkyl [(het) aryl] pyrazoles were synthesized via one-pot
nitrosation of 1, 3-diketones or their lithium salts followed by treatment of hydrazines …

Non‐opioid analgesics are widely used for pain relief in palliative medicine. However, there
is a lack of evidence‐based recommendations addressing the efficacy, tolerability, and …

This preliminary clinical investigation of the pharmacokinetic behavior of the main
metamizole (dipyrone) metabolites 4-methylaminoantipyrine (4-MAA) and 4-aminoantipyrine …

A visible‐light photoredox functionalization of 3, 4‐dihydro‐quinoxalin‐2‐ones with
pyrazolones using an inexpensive organophotoredox catalyst is described. The reaction …

Pain is a complex entity with deleterious effects on the entire organism. Poorly controlled
postoperative pain impacts the patient outcome, being associated with increased morbidity …