Cryo-EM advances in GPCR structure determination

W Shihoya, A Iwama, FK Sano… - The Journal of …, 2024 - academic.oup.com
G-protein-coupled receptors (GPCRs) constitute a prominent superfamily in humans and are
categorized into six classes (A–F) that play indispensable roles in cellular communication …

Structure, function and drug discovery of GPCR signaling

L Cheng, F Xia, Z Li, C Shen, Z Yang, H Hou… - Molecular …, 2023 - Springer
G protein-coupled receptors (GPCRs) are versatile and vital proteins involved in a wide
array of physiological processes and responses, such as sensory perception (eg, vision …

Supraspinal glycinergic neurotransmission in pain: A scoping review of current literature

C Fenech, BL Winters, Y Otsu… - Journal of …, 2024 - Wiley Online Library
The neurotransmitter glycine is an agonist at the strychnine‐sensitive glycine receptors. In
addition, it has recently been discovered to act at two new receptors, the excitatory glycine …

Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179

DN Patil, S Pantalone, Y Cao, T Laboute, SJ Novick… - Science …, 2023 - science.org
Precise synapse formation is essential for normal functioning of the nervous system. Retinal
photoreceptors establish selective contacts with bipolar cells, aligning the neurotransmitter …

Well-known polypeptides of deer antler velvet with key actives: modern pharmacological advances

H Sun, D Xiao, W Liu, X Li, Z Lin, Y Li… - … Archives of Pharmacology, 2024 - Springer
Deer antler velvet, with kidney tonifying, promoting the production of essence and blood,
strengthening tendons and bones, not only has a thousand-year medicinal history but also …

A machine learning analysis of big metabolomics data for classifying depression: Model development and validation

S Ma, X Xie, Z Deng, W Wang, D Xiang, L Yao… - Biological …, 2024 - Elsevier
Background Many metabolomics studies of depression have been performed, but these
have been limited by their scale. A comprehensive in silico analysis of global metabolite …

[HTML][HTML] The association of GNB5 with Alzheimer disease revealed by genomic analysis restricted to variants impacting gene function

J Zhang, M Pandey, A Awe, N Lue, C Kittock… - The American Journal of …, 2024 - cell.com
Disease-associated variants identified from genome-wide association studies (GWASs)
frequently map to non-coding areas of the genome such as introns and intergenic regions …

Molecular insights into the activation mechanism of GPR156 in maintaining auditory function

X Ma, LN Chen, M Liao, L Zhang, K Xi, J Guo… - Nature …, 2024 - nature.com
The class C orphan G-protein-coupled receptor (GPCR) GPR156, which lacks the large
extracellular region, plays a pivotal role in auditory function through G i2/3. Here, we firstly …

A neurotransmitter atlas of C. elegans males and hermaphrodites

C Wang, B Vidal, S Sural, C Loer, GR Aguilar… - Elife, 2024 - elifesciences.org
Mapping neurotransmitter identities to neurons is key to understanding information flow in a
nervous system. It also provides valuable entry points for studying the development and …

Clinical features in antiglycine receptor antibody-related disease: a case report and update literature review

X Wu, H Zhang, M Shi, S Fang - Frontiers in Immunology, 2024 - frontiersin.org
Background and objectives Antiglycine receptor (anti-GlyR) antibody mediates multiple
immune-related diseases. This study aimed to summarize the clinical features to enhance …