Leveraging the therapeutic, biological, and self-assembling potential of peptides for the treatment of viral infections

MK Monroe, H Wang, CF Anderson, H Jia… - Journal of Controlled …, 2022 - Elsevier
Peptides and peptide-based materials have an increasing role in the treatment of viral
infections through their use as active pharmaceutical ingredients, targeting moieties …

Potential of CXCR4/CXCL12 chemokine axis in cancer drug delivery

Y Wang, Y Xie, D Oupický - Current pharmacology reports, 2016 - Springer
This review discusses the potential of CXCR4 chemokine receptor in the design of
anticancer and antimetastatic drug delivery systems. The role of CXCR4 in cancer …

A bispecific glycopeptide spatiotemporally regulates tumor microenvironment for inhibiting bladder cancer recurrence

HW An, DY Hou, J Yang, ZQ Wang, MD Wang… - Science …, 2023 - science.org
Up to 75% of bladder cancer patients suffer from recurrence due to postoperative tumor
implantation. However, clinically used Bacillus Calmette-Guerin (BCG) treatment failed to …

Intracellular CXCR4+ cell targeting with T22-empowered protein-only nanoparticles

U Unzueta, MV Céspedes… - International journal …, 2012 - Taylor & Francis
Background Cell-targeting peptides or proteins are appealing tools in nanomedicine and
innovative medicines because they increase the local drug concentration and reduce …

CXCR4-Targeted Macrophage-Derived Biomimetic Hybrid Vesicle Nanoplatform for Enhanced Cancer Therapy through Codelivery of Manganese and Doxorubicin

Y Jang, YS Cho, A Kim, X Zhou, Y Kim… - … applied materials & …, 2024 - ACS Publications
Immune-cell-derived membranes have garnered significant attention as innovative delivery
modalities in cancer immunotherapy for their intrinsic immune-modulating functionalities and …

[HTML][HTML] Dual-function CXCR4 antagonist polyplexes to deliver gene therapy and inhibit cancer cell invasion

J Li, Y Zhu, ST Hazeldine, C Li… - … Chemie (International ed …, 2012 - ncbi.nlm.nih.gov
A bicyclam-based biodegradable polycation with CXCR4 antagonistic activity was
developed with potential for combined drug/gene cancer therapies. The dual-function …

Delivery of DNA vaccines: an overview on the use of biodegradable polymeric and magnetic nanoparticles

SD Xiang, C Selomulya, J Ho… - Wiley …, 2010 - Wiley Online Library
Vaccination offers a cost‐effective approach to the control of endemic infectious and a less
invasive treatment modality against cancers. Since the discovery that injecting DNA …

Serum-Resistant Ternary DNA Polyplexes for Suicide Gene Therapy of Uterine Leiomyoma

A Egorova, S Shtykalova, M Maretina, S Freund… - International Journal of …, 2023 - mdpi.com
Uterine leiomyoma (UL) is a prevalent benign tumor in women that frequently gives rise to a
multitude of reproductive complications. The use of suicide gene therapy has been …

The role of post-translational modifications of chemokines by CD26 in cancer

A De Zutter, J Van Damme, S Struyf - Cancers, 2021 - mdpi.com
Simple Summary Chemokines are central players in cancer and can be post-translationally
modified by dipeptidyl peptidase IV (DPPIV)/CD26. This can have different effects on …

CXCR4-targeted modular peptide carriers for efficient anti-VEGF siRNA delivery

A Egorova, A Shubina, D Sokolov, S Selkov… - International journal of …, 2016 - Elsevier
The application of small interfering RNA (siRNA) for specific gene inhibition is a promising
strategy in gene therapy treatments. The efficient cellular delivery of therapeutic siRNA is a …