[HTML][HTML] Ginsenosides for the treatment of metabolic syndrome and cardiovascular diseases: Pharmacology and mechanisms

W Fan, Y Huang, H Zheng, S Li, Z Li, L Yuan… - Biomedicine & …, 2020 - Elsevier
Epidemiological studies showed that the metabolic syndromes (MetS) and cardiovascular
diseases (CVDs) are responsible for a serious threat to human health worldwide. MetS is a …

[HTML][HTML] Functional roles and mechanisms of ginsenosides from Panax ginseng in atherosclerosis

Q Xue, N He, Z Wang, X Fu, LHH Aung, Y Liu… - Journal of ginseng …, 2021 - Elsevier
Atherosclerosis (AS) is a leading cause of cardiovascular diseases (CVDs) and it results in a
high rate of death worldwide, with an increased prevalence with age despite advances in …

[HTML][HTML] Comprehensive pharmacological and experimental study of Ginsenoside Re as a potential therapeutic agent for non-alcoholic fatty liver disease

J Zhang, M Duan, S Wu, S Jiang, S Hu, W Chen… - Biomedicine & …, 2024 - Elsevier
Abstract Objective Ginsenoside Re, a unique tetracyclic triterpenoid compound found in
ginseng, has been suggested in previous reports to improve non-alcoholic fatty liver disease …

Ginsenoside F2 Suppresses Adipogenesis in 3T3-L1 Cells and Obesity in Mice via the AMPK Pathway

J Zhou, J Zhang, J Li, Y Guan, T Shen, F Li… - Journal of Agricultural …, 2021 - ACS Publications
Ginsenoside F2 (GF2) is a protopanaxdiol saponin from Panax ginseng leaves and
possesses many potential pharmacological properties. GF2 may prevent obesity by directly …

Preventive effects of kaempferol on high‐fat diet‐induced obesity complications in C57BL/6 mice

T Wang, Q Wu, T Zhao - BioMed research international, 2020 - Wiley Online Library
Kaempferol is a dietary flavanol that regulates cellular lipid and glucose metabolism. Its
mechanism of action in preventing hepatic steatosis and obesity‐related disorders has yet to …

Minor ginsenoside Rg2 and Rh1 attenuates LPS-induced acute liver and kidney damages via downregulating activation of TLR4-STAT1 and inflammatory cytokine …

DTN Huynh, N Baek, S Sim, CS Myung… - International Journal of …, 2020 - mdpi.com
Ginsenosides have been reported to have various biological effects, such as immune
regulation and anticancer activity. In this study, we investigated the anti-inflammatory role of …

A review of saponin intervention in metabolic syndrome suggests further study on intestinal microbiota

Z Luo, W Xu, Y Zhang, L Di, J Shan - Pharmacological research, 2020 - Elsevier
Metabolic syndrome (MetS) is a series of symptoms including insulin resistance, obesity,
dyslipidemia, elevated fasting blood glucose levels, and hepatic steatosis. As a key criterion …

Protective effects of ginsenoside Rg2 against memory impairment and neuronal death induced by Aβ25-35 in rats

J Cui, R Shan, Y Cao, Y Zhou, C Liu, Y Fan - Journal of …, 2021 - Elsevier
Abstract Ethnopharmacological relevance Ginsenoside Rg2 is an important ingredient of
Panax ginseng which often appears in ancient prescriptions for forgetfulness. Ginsenoside …

Ginsenoside-Rg2 exerts anti-cancer effects through ROS-mediated AMPK activation associated mitochondrial damage and oxidation in MCF-7 cells

H Jeon, Y Jin, CS Myung, KS Heo - Archives of Pharmacal Research, 2021 - Springer
In this study, we investigated the anti-cancer effects of ginsenoside Rg2 (G-Rg2) and its
underlying signaling pathways in breast cancer (BC) cells. G-Rg2 significantly induced …

Protective effects of ginsenoside-Rg2 and-Rh1 on liver function through inhibiting TAK1 and STAT3-mediated inflammatory activity and Nrf2/ARE-mediated …

TLL Nguyen, DTN Huynh, Y Jin, H Jeon… - Archives of Pharmacal …, 2021 - Springer
Systemic or hepatic inflammation is caused by intraperitoneal application of
lipopolysaccharide (LPS). In this study, we investigated anti-inflammatory and antioxidant …