The advent of high-throughput single-cell transcriptomic analysis of microglia has revealed
different phenotypes that are inherently associated with disease conditions. A common …

Galectin-3 (Gal-3) is an evolutionarily conserved and multifunctional protein that drives
inflammation in disease. Gal-3's role in the central nervous system has been less studied …

An account of the neurobiology of motor recovery in the arm and hand after stroke by two
experts in the field. Stroke is a leading cause of disability in adults and recovery is often …

Stroke enhances proliferation of neural precursor cells within the subventricular zone (SVZ)
and induces ectopic migration of newborn cells towards the site of injury. Here, we …

Astrocytes react to brain injury in a heterogeneous manner with only a subset resuming
proliferation and acquiring stem cell properties in vitro. In order to identify novel regulators of …

Angiogenic response is essential for ischemic brain repair. The von Willebrand factor (VWF)–
cleaving protease disintegrin and metalloprotease with thrombospondin type I motif …

Emerging studies have demonstrated spinal microglia play a critical role in central
sensitization and contribute to chronic pain. Although several mediators that contribute to …

Galectin-3 (Gal-3) is the only chimeric protein in the galectin family. Gal-3 structure
comprises unusual tandem repeats of proline and glycine-rich short stretches bound to a …

Stroke not only causes initial cell death, but also a limited process of repair and recovery. As
an overall biological process, stroke has been most often considered from the perspective of …

In the adult mammalian brain, neural stem cells (NSCs) reside in two neurogenic regions,
the walls of the lateral ventricles, and the subgranular zone of the hippocampus, which …