Immunotherapy has emerged as a promising treatment paradigm for many malignancies
and is transforming the drug development landscape. Although immunotherapeutic agents …

Animal models play an indispensable role in the study of human diseases. However, animal
models of different diseases do not fully mimic the complex internal environment of humans …

Background Prophylactic and therapeutic vaccines often depend upon a strong activation of
the innate immune system to drive a potent adaptive immune response, often mediated by a …

Since the late 1980s, mice have been repopulated with human hematopoietic cells to study
the fundamental biology of human hematopoiesis and immunity, as well as a broad range of …

Monoamine oxidase A (MAO-A) is an enzyme best known for its function in the brain, where
it breaks down neurotransmitters and thereby influences mood and behavior. Small …

Invariant natural killer T (iNKT) cells are potent immune cells for targeting cancer; however,
their clinical application has been hindered by their low numbers in cancer patients. Here …

Immunotherapy has revolutionized cancer treatment, however, not all tumor types and
patients are completely responsive to this approach. Establishing predictive pre‐clinical …

High levels of IL1β can result in chronic inflammation, which in turn can promote tumor
growth and metastasis. Inhibition of IL1β could therefore be a promising therapeutic option …

Immunotherapy has established itself as a promising tool for cancer treatment. There are
many challenges that remain including lack of targets and some patients across various …

Simple Summary The clinical success of cancer immunotherapy targeting immune
checkpoints (eg, PD-1, CTLA-4) has ushered in a new era of cancer therapeutics aimed at …