Metabolomic and lipidomic biomarkers for premalignant liver disease diagnosis and therapy
In recent years, there has been a plethora of attempts to discover biomarkers that are more
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
reliable than α-fetoprotein for the early prediction and prognosis of hepatocellular carcinoma …
Eicosanoids and other oxylipins in liver injury, inflammation and liver cancer development
Liver cancer is a malignancy developed from underlying liver disease that encompasses
liver injury and metabolic disorders. The progression from these underlying liver disease to …
liver injury and metabolic disorders. The progression from these underlying liver disease to …
[HTML][HTML] Combination of CCl4 with alcoholic and metabolic injuries mimics human liver fibrosis
MJ Brol, F Rösch, R Schierwagen… - American Journal …, 2019 - journals.physiology.org
Metabolic and alcoholic liver injuries result in nonalcoholic (NAFLD) or alcoholic (ALD) fatty
liver disease, respectively. In particular, presence of fibrosis in NAFLD and ALD requires …
liver disease, respectively. In particular, presence of fibrosis in NAFLD and ALD requires …
[HTML][HTML] Animal models of NAFLD from the pathologist's point of view
H Denk, PM Abuja, K Zatloukal - … et Biophysica Acta (BBA)-Molecular Basis …, 2019 - Elsevier
Fatty liver disease is a multifactorial world-wide health problem resulting from a complex
interplay between liver, adipose tissue and intestine and initiated by alcohol abuse …
interplay between liver, adipose tissue and intestine and initiated by alcohol abuse …
Liver protective effect of fenofibrate in NASH/NAFLD animal models
Nonalcoholic fatty liver disease (NAFLD) is initiated by excessive fat buildup in the liver,
affecting around 35% of the world population. Various circumstances contribute to the …
affecting around 35% of the world population. Various circumstances contribute to the …
Cytochrome P450-derived eicosanoids and inflammation in liver diseases
Hepatic inflammation is a key pathologic mediator in a wide array of acute and chronic liver
diseases. Hepatitis is a crucial driver of liver tissue damage provoking the progression to …
diseases. Hepatitis is a crucial driver of liver tissue damage provoking the progression to …
[HTML][HTML] Targeting the eicosanoid pathway in hepatocellular carcinoma
A Razdan, NM Main, V Chiu, NA Shackel… - American journal of …, 2021 - ncbi.nlm.nih.gov
Liver cancer has variable incidence worldwide and high mortality. Histologically, the most
common subtype of liver cancer is hepatocellular carcinoma (HCC). Approximately 30-40 …
common subtype of liver cancer is hepatocellular carcinoma (HCC). Approximately 30-40 …
Hepatic macrophage mediated immune response in liver steatosis driven carcinogenesis
Obesity confers an independent risk for carcinogenesis. Classically viewed as a genetic
disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone …
disease, owing to the discovery of tumor suppressors and oncogenes, genetic events alone …
Genetics of metabolic syndrome: potential clues from wild-derived inbred mouse strains
S Karunakaran, SM Clee - Physiological Genomics, 2018 - journals.physiology.org
The metabolic syndrome (MetS) is a complex constellation of metabolic abnormalities
including obesity, abnormal glucose metabolism, dyslipidemia, and elevated blood pressure …
including obesity, abnormal glucose metabolism, dyslipidemia, and elevated blood pressure …
Investigating the deregulation of metabolic tasks via Minimum Network Enrichment Analysis (MiNEA) as applied to nonalcoholic fatty liver disease using mouse and …
V Pandey, V Hatzimanikatis - PLoS computational biology, 2019 - journals.plos.org
Nonalcoholic fatty liver disease (NAFLD) is associated with metabolic syndromes spanning
a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic …
a wide spectrum of diseases, from simple steatosis to the more complex nonalcoholic …