Platinum complexes are clinically used as adjuvant therapy of cancers aiming to induce
tumor cell death. Depending on cell type and concentration, cisplatin induces cytotoxicity …

Osteosarcoma is the most common primary malignancy of bone. It arises in bone during
periods of rapid growth and primarily affects adolescents and young adults. The 5‐year …

A novel multifunctional nanodevice based in doxorubicin (DOX)-loaded mesoporous silica
nanoparticles (MSNs) as nanoplatforms for the assembly of different building blocks has …

Cancer treatment that uses a combination of approaches with the ability to affect multiple
disease pathways has been proven highly effective in the treatment of many cancers …

Simple Summary Treatment of osteosarcoma, apart from chemotherapy modifications, has
not changed for approximately 30 years. Similarly, as in other tumors, mutations in the TP53 …

DNA replication is a highly demanding process regarding the energy and material supply
and must be precisely regulated, involving multiple cellular feedbacks. The slowing down or …

In this study, we demonstrate how functional groups on the surface of mesoporous silica
nanoparticles (MSNPs) can influence the encapsulation and release of the anticancer drug …

Development of chemotherapeutic treatment modalities resulted in a dramatic increase in
the survival of children with many types of cancer. Still, in case of some pediatric cancer …

Osteosarcoma is the most frequent primary bone tumor and occurs mainly in young patients
(average age: 18 years). No evolution of the survival rates has been recorded for two …

Background Osteosarcoma (OS) is a malignant tumor of the bone mostly observed in
children and adolescents. The current treatment approach includes neoadjuvant and …