Reverse phase protein arrays—quantitative assessment of multiple biomarkers in biopsies for clinical use

S Boellner, KF Becker - Microarrays, 2015 - mdpi.com
Reverse Phase Protein Arrays (RPPA) represent a very promising sensitive and precise
high-throughput technology for the quantitative measurement of hundreds of signaling …

New era of integrated cancer biomarker discovery using reverse-phase protein arrays

SS Nishizuka, GB Mills - Drug metabolism and pharmacokinetics, 2016 - Elsevier
The ultimate goal of cancer biomarker discovery is to use individual patient-derived
biochemical information to improve patients' outcomes. A recent increase in the spectrum of …

Drug synergy screen and network modeling in dedifferentiated liposarcoma identifies CDK4 and IGF1R as synergistic drug targets

ML Miller, EJ Molinelli, JS Nair, T Sheikh, R Samy… - Science …, 2013 - science.org
Dedifferentiated liposarcoma (DDLS) is a rare but aggressive cancer with high recurrence
and low response rates to targeted therapies. Increasing treatment efficacy may require …

Blood-based biomarkers of repetitive, subconcussive blast overpressure exposure in the training environment: a pilot study

DV Agoston, J McCullough, R Aniceto, IH Lin… - Neurotrauma …, 2022 - liebertpub.com
Because of their unknown long-term effects, repeated mild traumatic brain injuries (TBIs),
including the low, subconcussive ones, represent a specific challenge to healthcare …

Integrative multi-OMICs identifies therapeutic response biomarkers and confirms fidelity of clinically annotated, serially passaged patient-derived xenografts …

PH Pandya, AJ Jannu, K Bijangi-Vishehsaraei… - Cancers, 2022 - mdpi.com
Simple Summary Solid tumors account for~ 60% of pediatric, as well as adolescent and
young adult (AYA), cancers, and outcomes for patients with these progressive diseases …

RPPA SPACE: an R package for normalization and quantitation of Reverse-Phase Protein Array data

H Shehwana, SV Kumar, JM Melott… - …, 2022 - academic.oup.com
Abstract Summary Reverse-Phase Protein Array (RPPA) is a robust high-throughput, cost-
effective platform for quantitatively measuring proteins in biological specimens. However …

Proteomic screening and lasso regression reveal differential signaling in insulin and insulin-like growth factor I (IGF1) pathways

C Erdem, AM Nagle, AJ Casa, BC Litzenburger… - Molecular & Cellular …, 2016 - ASBMB
Insulin and insulin-like growth factor I (IGF1) influence cancer risk and progression through
poorly understood mechanisms. To better understand the roles of insulin and IGF1 signaling …

Integrative analysis of multi-platform reverse-phase protein array data for the pharmacodynamic assessment of response to targeted therapies

A Byron, S Bernhardt, B Ouine, A Cartier… - Scientific Reports, 2020 - nature.com
Reverse-phase protein array (RPPA) technology uses panels of high-specificity antibodies
to measure proteins and protein post-translational modifications in cells and tissues. The …

Procollagen markers in microdialysate can predict patient outcome after Achilles tendon rupture

MA Alim, S Svedman, G Edman… - BMJ open sport & …, 2016 - bmjopensem.bmj.com
Objective Patients who sustain acute Achilles tendon rupture (ATR) exhibit variable and
mostly impaired long-term functional, and patient-reported outcomes. However, there exists …

SeNMo: A self-normalizing deep learning model for enhanced multi-omics data analysis in oncology

A Waqas, A Tripathi, S Ahmed, A Mukund… - arXiv preprint arXiv …, 2024 - arxiv.org
Multi-omics research has enhanced our understanding of cancer heterogeneity and
progression. Investigating molecular data through multi-omics approaches is crucial for …