The past decade has produced an explosion in the number and variety of genetic tools
available to neuroscientists, resulting in an unprecedented ability to precisely manipulate …

It has been nearly two decades since RNA‐interference (RNAi) was first reported. While
there are no approved clinical uses, several phase II and III clinical trials suggest the great …

Major depressive disorder is among the most commonly diagnosed disabling mental
diseases. Several non-pharmacological treatments of depression upregulate adenosine …

Diabetic hyperglycemia aggravates the prognosis of intracerebral hemorrhagic stroke (ICH)
in the clinic. In addition to hematoma expansion and increased inflammation, how diabetic …

Abstract cGAS is a sensor of cytosolic DNA and responds equally to exogenous and
endogenous DNA. After recognition of cytosolic dsDNA or ssDNA, cGAS synthesizes the …

Neuronal histone H3-lysine 4 methylation landscapes are defined by sharp peaks at gene
promoters and other cis-regulatory sequences, but molecular and cellular phenotypes after …

Huntington's disease (HD) is a rare autosomal dominant neurodegenerative disease caused
by the expression of a toxic Huntingtin (HTT) protein. The use of short interfering RNAs …

Background: Microglia can not only detrimentally augment secondary injury but also
potentially promote recovery. However, the mechanism underlying the regulation of …

Breast cancer is the most frequently diagnosed malignancy in American women. While
significant progress has been made in the development of modern diagnostic tools and …

Abstract Matrix metalloproteinase 13 (MMP13) and a disintegrin and metalloproteinase with
thrombospondin motifs 5 (ADAMTS5) are thought to play critical roles in cartilage …