Besides its role as an energy storage organ, adipose tissue can be viewed as a dynamic
and complex endocrine organ, which produces and secretes several adipokines, including …

Background There is currently an unmet clinical need to develop better pharmacological
treatments to improve glucose handling in Type II Diabetes patients with obesity. To this end …

The risk of chronic diseases caused by aging is reduced by caloric restriction (CR)-induced
immunometabolic adaptation. Here, we found that the matricellular protein, secreted protein …

There is growing evidence that chronic inflammation plays a role in both the development
and progression of diabetic retinopathy. There is also evidence that molecules produced as …

Whereas hypertension, diabetes, and dyslipidemia are age-related risk factors for
cardiovascular disease (CVD) and chronic kidney disease (CKD), aging alone is an …

Secreted protein acidic and rich in cysteine (SPARC) is an extracellular matrix glycoprotein
with pleiotropic functions, which is expressed in adipose, hepatic, muscular, and pancreatic …

To investigate the role of secreted protein acidic and rich in cysteine (SPARC) in age-related
cardiac inflammation, we studied six groups of mice: young (3–5 mo old), middle-aged (10 …

Objective To determine the difference of serum levels of 10 adipokines (apelin, chemerin,
fatty acid-binding protein-4, fibroblast growth factor-21, monocyte chemoattractant protein-1 …

The musculoskeletal system consisting of bones and muscles have been recognized as
endocrine organs secreting hormones that are involved in regulating metabolic and …

Background The role of adipokine dysregulation in determining the metabolic fate of obesity
is not well studied. We aimed to examine whether the matricellular protein osteonectin and …