There is increasing awareness of the ubiquitous role of oxidative stress in
neurodegenerative disease states. A continuing challenge is to be able to distinguish …

During the last three decades, 4-hydroxy-2-nonenal (HNE), a major α, β-unsaturated
aldehyde product of n-6 fatty acid oxidation, has been shown to be involved in a great …

Background and aims Chronic inflammation, induced by biological, chemical, and physical
factors, was associated with increased risk of human cancer at various sites. Chronic …

A comprehensive focus on 4‐hydroxynonenal (HNE) as candidate molecule in a variety of
pathophysiological conditions occurring in humans is here provided. Despite an active, now …

Unsaturated fatty acids are prone to radical reactions that occur in biological situations
where extensive formation of reactive oxygen and nitrogen species (ROS and RNS) takes …

Biological electrophiles result from oxidative metabolism of exogenous compounds or
endogenous cellular constituents, and they contribute to pathophysiologies such as toxicity …

Obesity is a state of mild inflammation correlated with increased oxidative stress. In general,
pro-oxidative conditions lead to production of reactive aldehydes such as trans-4-hydroxy-2 …

Stress response pathways allow cells to sense and respond to environmental changes and
adverse pathophysiological states. Pharmacological modulation of cellular stress pathways …

Renalase is a novel flavoprotein, highly expressed in kidney and heart, which metabolizes
catecholamines and catecholamine-like substances via a superoxide (O2–)-dependent …

Over the last 50 years, the posttranslational modification (PTM) of proteins has emerged as a
central mechanism for cells to regulate metabolism, growth, differentiation, cell-cell …