PKC family consist of a number of serine-threonine kinases which are divided into three
groups based on their activating factors. PKCs have been linked to carcinogenesis since …

In eukaryotic cells, control mechanisms have developed that restrain cell-cycle transitions in
response to stress. These regulatory pathways are termed cell-cycle checkpoints. The G 2/M …

DNA damage and replication stress activate the Chk1 signaling pathway, which blocks S
phase progression, stabilizes stalled replication forks, and participates in G 2 arrest. In this …

Although promising new radiation therapy techniques such as hadrontherapy are currently
being evaluated in the treatment of head and neck malignancies, local control of head and …

Purpose: Because of the potential for affecting multiple signaling pathways, inhibition of
Hsp90 may provide a strategy for enhancing tumor cell radiosensitivity. Therefore, we have …

Apoptosis, known as programmed cell death, is a conserved, gene-directed mechanism for
the elimination of unnecessary or unwanted cells from an organism. A retrospective look at …

Abstract Cisplatin (CDDP: cis-diamminedichloroplatinum) resistance is a major hurdle in the
treatment of human ovarian cancer (OVCA). A better understanding of the mechanisms of …

In the last three decades, gemcitabine has progressed from the status of a laboratory
cytotoxic drug to a standard clinical chemotherapeutic agent and a potent radiation …

Low-dose hyper-radiosensitivity describes a phenomenon by which cells die from excessive
sensitivity to small single doses of ionizing radiation below∼ 20–30 cGy. This review …

Background Lung cancer is the most lethal cancer, and 85% of cases are classified as non-
small cell lung cancer (NSCLC). Metabolic rewiring is a cancer hallmark that causes …