Protein SUMOylation is a major post-translational modification essential for maintaining
cellular homeostasis. SUMOylation has long been associated with stress responses as a …

Oncolytic viral (OV) therapies are promising novel treatment modalities for cancers refractory
to conventional treatment, such as glioblastoma, within the central nervous system (CNS) …

Novel targeted agents used in therapy of lymphoid malignancies are recognized to have
complex immune-mediated effects. Sumoylation, a posttranslational modification of target …

Mantle cell lymphoma (MCL) is an incurable B-cell malignancy with an overall poor
prognosis, particularly for patients that progress on targeted therapies. Novel, more durable …

Mantle cell lymphoma (MCL) is an incurable B-cell non-Hodgkin lymphoma, and patients
who relapse on targeted therapies have poor prognosis. Protein arginine methyltransferase …

Though cancer treatments have advanced significantly over the last few decades, drug
resistance is responsible for 90% of cancer related deaths. Next generation sequencing …

Lymphoma is a cancer that affects white blood cells called “lymphocytes” found in the
lymphatic system. Each year approximately 580,000 people are diagnosed with lymphoma …

Abstract Mantle Cell Lymphoma (MCL) is a B cell lymphoma distinguished from other B cell
lymphomas by at (11; 14)(q13: q32) translocation juxtaposing the CCND1 gene downstream …