Cancer is the second leading cause of human death globally. PI3K/Akt/mTOR signaling is
one of the most frequently dysregulated signaling pathways observed in cancer patients that …

The biochemical role of the PI3K/PKB/mTOR signalling pathway in cell-cycle regulation is
now well known. During the onset and development of different forms of cancer it becomes …

A new mode of cell death, disulfidptosis, has been discovered. Clinical prognostic
significance of disulfidptosis related pattern in hepatocellular carcinoma (HCC). In this study …

Although chimeric antigen receptor (CAR)–modified T cells have shown great success in the
treatment of B cell malignancies, this approach has limited efficacy in patients with solid …

Cancer is a devastating disease that has plagued humans from ancient times to this day.
After decades of slow research progress, promising drug development, and the identification …

Chronic myeloid leukemia (CML), a myeloproliferative hematopoietic cancer, is caused by a
genetic translocation between chromosomes 9 and 22. This translocation produces a small …

Despite a long appreciation for the role of nonsense-mediated mRNA decay (NMD) in
destroying faulty, disease-causing mRNAs and maintaining normal, physiologic mRNA …

Curcumin, a phytochemical from rhizomes of the plant Curcuma longa, has been reported to
exert potential anticancer properties in various cancer types, including acute myeloid …

The reduction in androgen synthesis and the blockade of the androgen receptor (AR)
function by chemical castration and AR signaling inhibitors represent the main treatment …

Abstract Ethnopharmacological relevance Dioscorea nipponica Makino as a Chinese folk
medicine has been used for the treatment of chronic bronchitis, cough, and asthma. Several …