Recent advances have contributed to a mechanistic understanding of neuroimmune
interactions in the intestine and revealed an essential role of this cross talk for gut …

Enteric glia are the partners of neurons in the enteric nervous system throughout the
gastrointestinal tract. Roles fulfilled by enteric glia are diverse and contribute to maintaining …

Highlights•Enteric glial cells (EGCs) are required for maintenance of gut tissue
homeostasis.•GFAP+ EGCs regulate the health of the intestinal epithelial barrier.•EGCs …

Dysregulated cell-cell communication is a hallmark of many disease phenotypes. Due to
recent advances in single-cell transcriptomics and computational approaches, it is now …

The gastrointestinal tract is innervated by the enteric nervous system (ENS), a complex
network of neurons and glial cells, also called the “second brain”. Enteric glial cells, one of …

Children with neurodegenerative disease often have debilitating gastrointestinal symptoms.
We hypothesized that this may be due at least in part to underappreciated degeneration of …

Enteric glia have been recently recognized as key components of the colonic tumor
microenvironment indicating their potential role in colorectal cancer pathogenesis. Although …

Enteric glia are a unique type of peripheral neuroglia that accompany neurons in the enteric
nervous system (ENS) of the digestive tract. The ENS displays integrative neural circuits that …

Enteric glial cells (EGCs) are an essential component of the enteric nervous system (ENS)
and play key roles in gastrointestinal development, homeostasis, and disease. Derived from …

The intestinal mucosal surface forms one of the largest areas of the body, which is in direct
contact with the environment. Co-ordinated sensory functions of immune, epithelial, and …