Morphological observations have driven the course of biology ever since the first
microscope was built in the late sixteenth century. Molecular imaging is a rapidly emerging …

Optical sensing of specific molecular targets and pathways deep inside living mice has
become possible as a result of a number of advances. These include design of …

This study examines transgene expression and biodistribution of adeno-associated virus
(AAV) pseudotyped 1–9 after tail vein (TV) injection in male mice. Using a cytomegalovirus …

BACKGROUND & AIMS: Staging inadequately predicts metastatic risk in patients with colon
cancer. We used a gene expression profile derived from invasive, murine colon cancer cells …

An important risk in the clinical application of human pluripotent stem cells (hPSCs),
including human embryonic and induced pluripotent stem cells (hESCs and hiPSCs), is …

Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles that are released by almost
all cell types. They range in diameter from 30 nm to several micrometres and have the ability …

Luciferases, which have seen expansive employment as reporter genes in biological
research, could also be used in applications where the protein itself is conjugated to ligands …

Bioluminescent and fluorescent reporters are finding increased use in optical molecular
imaging in small animals. In the work presented here, issues related to the sensitivity of in …

Imaging reporter gene expression in living subjects is a rapidly evolving area of molecular
imaging research. Studies have validated the use of reporter genes with positron emission …

Luciferases are enzymes that emit light in the presence of oxygen and a substrate (luciferin)
and which have been used for real‐time, low‐light imaging of gene expression in cell …