Astrocytes regulate potassium and glutamate homeostasis via inwardly rectifying potassium
(Kir) 4.1 channels in synapses, maintaining normal neural excitability. Numerous studies …

Seizures are a frequent pathophysiological feature of malignant glioma. Recent studies
implicate peritumoral synaptic dysregulation as a driver of brain hyperactivity and tumor …

Background Although the group of paroxysmal kinesigenic dyskinesia (PKD) genes is
expanding, the molecular cause remains elusive in more than 50% of cases. Objective The …

Objective Most paroxysmal kinesigenic dyskinesia (PKD) cases are hereditary, yet
approximately 60% of patients remain genetically undiagnosed. We undertook the present …

Epilepsy is a devastating neurological disorder characterized by recurrent seizures
attributed to the disruption of the dynamic excitatory and inhibitory balance in the brain …

In 2009, two groups independently linked human mutations in the inwardly rectifying K+
channel Kir4. 1 (gene name KCNJ10) to a syndrome affecting the central nervous system …

KCNJ10 encodes the inward-rectifying potassium channel (Kir4. 1) that is expressed in the
brain, inner ear, and kidney. Loss-of-function mutations in KCNJ10 gene cause a complex …

Epilepsy is defined as having 2 or more unprovoked seizures and may arise after acquired
brain injury, including traumatic brain injury, or various insults related to inflammation …

EAST/SeSAME syndrome is a rare disease affecting the Central Nervous System (CNS),
inner ear, and kidney. The syndrome is due to loss-of-function mutations in the KCNJ10 …

The normal aging process is accompanied by cognitive decline, and previous studies have
indicated the crucial role of the hypothalamus in regulating both aging and cognition …