A wound is a temporary break in the continuity of the protective skin barrier. Wound healing
is central in maintaining the body's normal homeostatic mechanism, and open wounds raise …

Lameness is a leading cause of welfare and culling issues in cattle, with claw lesions
accounting for the majority of these issues. Although the treatment of claw lesions in cattle is …

Cigarette smoking (CS) has been associated with an increased risk of cognitive disorders.
Although HMGB1 has been connected to various neurological ailments, its role in the …

Up to 15 billion dollars of US health care expenditure each year is consumed by treatment of
poorly healing wounds whose etiologies are often associated with aberrancies in tissue …

Aims Activation of endoplasmic reticulum stress (ERS) by particulate matter 2.5 (PM 2.5) has
recently been linked to an increased risk of heart problems. Although the PERK-eIF2α …

Background Impaired cutaneous wound healing is common in humans, and treatments are
often ineffective. Based on the significant emotional and economic burden of impaired …

Significance: Cutaneous wounds are a major problem in both human and equine medicine.
The economic cost of treating skin wounds and related complications in humans and horses …

The formation of exuberant granulation tissue (EGT) is a frequent complication of wounds
healing by second intention on the limbs of horses. Among the large number of contributing …

Topical cleaning agents should provide antisepsis but should not be cytotoxic to the healthy
tissue within a wound. Prior to antiseptic application, a wound should be prepared by …

Delayed healing associated with distal limb wounds is highly challenging in equine clinical
practice. This study aimed to evaluate healing rates between chronic non-granulating …