The widespread use of antibiotics in the past 80 years has saved millions of human lives,
facilitated technological progress and killed incalculable numbers of microbes, both …

Our ability to generate bacterial strains with unique and increasingly complex functions has
rapidly expanded in recent times. The capacity for DNA synthesis is increasing and costing …

Bacteria can be genetically engineered to kill specific pathogens or inhibit their virulence.
We previously developed a synthetic genetic system that allows a laboratory strain of …

The ability to rationally engineer microorganisms has been a long-envisioned goal dating
back more than a half-century. With the genomics revolution and rise of systems biology in …

Cells navigate environments, communicate and build complex patterns by initiating gene
expression in response to specific signals. Engineers seek to harness this capability to …

BACKGROUND Microbial communities are ubiquitous on Earth. The microbiota of different
habitats are diverse and have distinct functional traits, but there are common ecological …

Quorum sensing (QS), a microbial cell-to-cell communication process, dynamically regulates
a variety of metabolism and physiological activities. In this review, we provide an update on …

The mammalian gut is a dynamic community of symbiotic microbes that interact with the host
to impact health, disease, and metabolism. We constructed engineered bacteria that survive …

Highlights•Microbial communities are naturally abundant.•Natural symbioses exhibit
increased robustness and metabolic capabilities.•Technological advances in environmental …

Engineered live bacteria could provide a new modality for treating lung infections, a major
cause of mortality worldwide. In the present study, we engineered a genome-reduced …