The release of cytokines by T cells defines a significant part of their functional activity in vivo,
and their ability to produce multiple cytokines has been associated with beneficial immune …

Naturally derived regulatory T (Treg) cells are characterized by stable expression of the
transcription factor Foxp3 and characteristic epigenetic imprinting at the Foxp3 gene locus …

The interplay between inflammatory and regulatory pathways orchestrates an effective
immune response that provides protection from pathogens while limiting injury to host tissue …

Genome-wide association studies (GWAS) have identified over 300 regions associated with
more than 70 common diseases. However, identifying causal genes within an associated …

The intracellular signaling molecule TRAF6 is critical for Toll-like receptor (TLR)-mediated
activation of dendritic cells (DCs). We now report that DC-specific deletion of TRAF6 …

The interaction of T cells with antigen‐presenting cells is the hallmark of adaptive immunity.
In vitro studies have described the formation of an immunological synapse between these …

Tumor specific Th9 cells are potential effector cells for adoptive therapy of human cancers.
TNF family members OX40L, TL1A and GITRL have been shown to promote the induction of …

TNF-α antagonists provide benefit to patients with inflammatory autoimmune disorders such
as Crohn's disease, rheumatoid arthritis, and ankylosing spondylitis. However, TNF …

The double-edged sword nature by which IL-2 regulates autoimmunity and the
unpredictable outcomes of anti-TNF therapy in autoimmunity highlight the importance for …

Tumor necrosis factor-α (TNF-α) signaling through TNF receptor 2 (TNFR2) plays a complex
immune regulatory role in allogeneic hematopoietic cell transplantation (HCT). TNF-α is …