Drug resistant tuberculosis contributes significantly to the global burden of antimicrobial
resistance, often consuming a large proportion of the healthcare budget and associated …

Cellular decision making is the process whereby cells assume different, functionally
important and heritable fates without an associated genetic or environmental difference …

Multi-component signal transduction pathways and gene regulatory circuits underpin
integrated cellular responses to perturbations. A recurring set of network motifs serve as the …

Tandem repeats of DNA that contain transcription factor (TF) binding sites could serve as
decoys, competitively binding to TFs and affecting target gene expression. Using a synthetic …

The treatment of tuberculosis is extremely long. One of the reasons why Mycobacterium
tuberculosis elimination from the organism takes so long is that in particular environmental …

The granuloma is the defining feature of the host response to infection with Mycobacterium
tuberculosis (Mtb). Despite knowing of its existence for centuries, much remains unclear …

Natural biological systems have evolved a diverse array of switches to realize their
strategies for environmental response and development. Emerging applications of synthetic …

The terms “genotype” and “phenotype” were coined by the botanist and geneticist Wilhelm
Johannsen at the beginning of the 20th century (1). Both words have a Greek etymology …

The balance between cellular proliferation and differentiation is a key aspect of development
in multicellular organisms. Recent studies on Arabidopsis roots revealed distinct roles for …

The emergence and spread of drug-resistant Mycobacterium tuberculosis strains possibly
threaten our ability to treat this disease in the future. Even though two new antitubercular …